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Literature summary extracted from
- Enzymic synthesis of juvenile hormone in locust corpora allata: evidence for a microsomal cytochrome P-450 linked methyl farnesoate epoxidase (1981), Eur. J. Biochem., 118, 231-238.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.127 | carbon monoxide/oxygen atmosphere | half-maximal inhibition at a CO/O ratio of 4.0. Inhibition is reversed by white-light irradiation | Locusta migratoria | |
| 1.14.14.127 | cytochrome c | inhibition by oxidized cytochrome c, 20 microM, 52.4% residual activity | Locusta migratoria |  |
| 1.14.14.127 | NADP+ | 2 mM, 57.2% residual activity | Locusta migratoria | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.127 | 0.0077 | - |
methyl (2E,6E)-farnesoate | pH 8.0, 30°C | Locusta migratoria | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.127 | microsome | exclusively microsomal | Locusta migratoria | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.127 | Locusta migratoria | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.127 | methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 | - |
Locusta migratoria | juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O | 2E,6E isomer, product has 10R configuration | ? | |
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