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Literature summary extracted from

  • Mashimo, M.; Kato, J.; Moss, J.
    Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases (2014), DNA Repair, 23, 88-94.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.31 cytoplasm
-
 Homo sapiens 5737
-
3.2.2.19 cytoplasm isoform ARH1 and ARH3 Mus musculus 5737
-
3.2.2.19 mitochondrion isoform ARH3 Mus musculus 5739
-
3.2.2.19 nucleus isoform ARH3 Mus musculus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.2.2.19 Mg2+ enzymatic activity requires 2 Mg2+ Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.31 NAD+ + protein L-arginine Homo sapiens
-
 nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
-
 ?
3.2.2.19 ADP-ribose-arginine + H2O Mus musculus
-
 ADP-ribose + arginine
-
 ?
3.2.2.19 O-acetyl-ADP-ribose + H2O Mus musculus the reaction is catalyzed by isoform ARH3 only ADP-ribose + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.31 Homo sapiens
-
-
-
3.2.2.19 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.31 NAD+ + protein L-arginine
-
 Homo sapiens nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
-
 ?
3.2.2.19 ADP-ribose-arginine + H2O
-
 Mus musculus ADP-ribose + arginine
-
 ?
3.2.2.19 additional information isoform ARH1 catalyzes the hydrolysis of the N-glycosidic bond of mono-(ADP-ribosyl)ated arginine, while isoform ARH3 hydrolyzes poly-(ADP-ribose) and O-acetyl-ADP-ribose Mus musculus ?
-
 ?
3.2.2.19 O-acetyl-ADP-ribose + H2O the reaction is catalyzed by isoform ARH3 only Mus musculus ADP-ribose + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.31 ADP-ribosyl-acceptor hydrolase 1
-
 Homo sapiens
2.4.2.31 ARH1
-
 Homo sapiens
2.4.2.31 mono-ADP-ribosyl-arginine hydrolase
-
 Homo sapiens
3.2.2.19 ADP-ribosyl-acceptor hydrolase
-
 Mus musculus
3.2.2.19 ARH1 isoform Mus musculus
3.2.2.19 ARH3 isoform Mus musculus
3.2.2.19 mono-ADP-ribosyl-arginine hydrolase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.4.2.31 physiological function the enzyme is involved in the action by bacterial toxins as well as in tumorigenesis Homo sapiens
3.2.2.19 physiological function isoform ARH1 is involved in the action by bacterial toxins as well as intumorigenesis. Isoform ARH3 participates in the degradation of poly-(ADP-ribose) that is synthesized by poly-(ADP-ribose) polymerase 1 in response to oxidative stress-induced DNA damage. Isoform ARH1 is involved in estrogen-stimulated tumorigenesis. Isoform ARH3 is involved in the regulation of parthanatos (PARP1-dependent cell death) Mus musculus