BRENDA - Enzyme Database show

Cholesterol epoxide hydrolase and cancer

Silvente-Poirot, S.; Poirot, M.; Curr. Opin. Pharmacol. 12, 696-703 (2012)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.3.2.11
4-hydroxy-tamoxifen
-
Homo sapiens
3.3.2.11
6-ketocholestanol
-
Homo sapiens
3.3.2.11
7-ketocholestanol
-
Homo sapiens
3.3.2.11
7-ketocholesterol
-
Homo sapiens
3.3.2.11
alpha-linolenic acid
-
Homo sapiens
3.3.2.11
amiodarone
-
Homo sapiens
3.3.2.11
arachidonic acid
-
Homo sapiens
3.3.2.11
cholestane-3beta,5alpha,6beta-triol
-
Homo sapiens
3.3.2.11
clomiphene
-
Homo sapiens
3.3.2.11
docosahexaenoic acid
-
Homo sapiens
3.3.2.11
haloperidol
-
Homo sapiens
3.3.2.11
N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine
-
Homo sapiens
3.3.2.11
oleic acid
-
Homo sapiens
3.3.2.11
raloxifene
-
Homo sapiens
3.3.2.11
SR31747A
-
Homo sapiens
3.3.2.11
tamoxifen
-
Homo sapiens
3.3.2.11
terbinafine
-
Homo sapiens
3.3.2.11
tesmilifene
-
Homo sapiens
3.3.2.11
trifluoroperazine
-
Homo sapiens
3.3.2.11
U-18666A
-
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.3.2.11
endoplasmic reticulum
-
Homo sapiens
5783
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.3.2.11
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O
Homo sapiens
-
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
?
3.3.2.11
5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O
Homo sapiens
better substrate
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.3.2.11
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.3.2.11
brain
-
Homo sapiens
-
3.3.2.11
intestinal epithelium
-
Homo sapiens
-
3.3.2.11
kidney
-
Homo sapiens
-
3.3.2.11
liver
richest source tissue
Homo sapiens
-
3.3.2.11
lung
-
Homo sapiens
-
3.3.2.11
MCF-7 cell
-
Homo sapiens
-
3.3.2.11
skin
-
Homo sapiens
-
3.3.2.11
spleen
-
Homo sapiens
-
3.3.2.11
testis
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.3.2.11
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O
-
731693
Homo sapiens
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
3.3.2.11
5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O
better substrate
731693
Homo sapiens
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
3.3.2.11
0.000006
-
SR31747A
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000027
-
N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000034
-
tamoxifen
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000036
-
raloxifene
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000062
-
tesmilifene
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.00009
-
U-18666A
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000135
-
trifluoroperazine
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000145
-
4-hydroxy-tamoxifen
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000733
-
amiodarone
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.0042
-
7-ketocholesterol
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.0091
-
terbinafine
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.0097
-
cholestane-3beta,5alpha,6beta-triol
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.012
-
docosahexaenoic acid
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.018
-
haloperidol
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.024
-
arachidonic acid
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.036
-
alpha-linolenic acid
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.054
-
oleic acid
pH and temperature not specified in the publication
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.3.2.11
4-hydroxy-tamoxifen
-
Homo sapiens
3.3.2.11
6-ketocholestanol
-
Homo sapiens
3.3.2.11
7-ketocholestanol
-
Homo sapiens
3.3.2.11
7-ketocholesterol
-
Homo sapiens
3.3.2.11
alpha-linolenic acid
-
Homo sapiens
3.3.2.11
amiodarone
-
Homo sapiens
3.3.2.11
arachidonic acid
-
Homo sapiens
3.3.2.11
cholestane-3beta,5alpha,6beta-triol
-
Homo sapiens
3.3.2.11
clomiphene
-
Homo sapiens
3.3.2.11
docosahexaenoic acid
-
Homo sapiens
3.3.2.11
haloperidol
-
Homo sapiens
3.3.2.11
N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine
-
Homo sapiens
3.3.2.11
oleic acid
-
Homo sapiens
3.3.2.11
raloxifene
-
Homo sapiens
3.3.2.11
SR31747A
-
Homo sapiens
3.3.2.11
tamoxifen
-
Homo sapiens
3.3.2.11
terbinafine
-
Homo sapiens
3.3.2.11
tesmilifene
-
Homo sapiens
3.3.2.11
trifluoroperazine
-
Homo sapiens
3.3.2.11
U-18666A
-
Homo sapiens
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
3.3.2.11
0.000006
-
SR31747A
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000027
-
N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000034
-
tamoxifen
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000036
-
raloxifene
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000062
-
tesmilifene
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.00009
-
U-18666A
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000135
-
trifluoroperazine
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000145
-
4-hydroxy-tamoxifen
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.000733
-
amiodarone
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.0042
-
7-ketocholesterol
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.0091
-
terbinafine
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.0097
-
cholestane-3beta,5alpha,6beta-triol
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.012
-
docosahexaenoic acid
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.018
-
haloperidol
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.024
-
arachidonic acid
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.036
-
alpha-linolenic acid
pH and temperature not specified in the publication
Homo sapiens
3.3.2.11
0.054
-
oleic acid
pH and temperature not specified in the publication
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.3.2.11
endoplasmic reticulum
-
Homo sapiens
5783
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.3.2.11
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O
Homo sapiens
-
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
?
3.3.2.11
5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O
Homo sapiens
better substrate
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.3.2.11
brain
-
Homo sapiens
-
3.3.2.11
intestinal epithelium
-
Homo sapiens
-
3.3.2.11
kidney
-
Homo sapiens
-
3.3.2.11
liver
richest source tissue
Homo sapiens
-
3.3.2.11
lung
-
Homo sapiens
-
3.3.2.11
MCF-7 cell
-
Homo sapiens
-
3.3.2.11
skin
-
Homo sapiens
-
3.3.2.11
spleen
-
Homo sapiens
-
3.3.2.11
testis
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.3.2.11
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O
-
731693
Homo sapiens
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
3.3.2.11
5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O
better substrate
731693
Homo sapiens
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
3.3.2.11
physiological function
the enzyme plays a potential role in cancer progression and resistance
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.3.2.11
physiological function
the enzyme plays a potential role in cancer progression and resistance
Homo sapiens