EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.13.2.1 | 2-((2-((2-(diethylamino)ethyl)amino)-2-oxoethyl)(4-fluorophenyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | 4.56% inhibition at 0.0025 mM; 8.23% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | 2-((2-((2-(diethylamino)ethyl)amino)-2-oxoethyl)(4-tolyl)-amino)-N-(isoindolin-2-yl)-N-methylacetamide | 4.89% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | 2-((2-((2-(diethylamino)ethyl)amino)-2-oxoethyl)-(1-methyl-1H-indazol-5-yl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | 30.19% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | 2-((2-((2-(diethylamino)ethyl)amino)-2-oxoethyl)-(2-methyl-2H-indazol-5-yl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | 27.15% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | 2-((2-((2-(ethylamino)ethyl)amino)-2-oxoethyl)(1-methyl-1H-indazol-5-yl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | 85.72% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | 2-((2-((2-(ethylamino)ethyl)amino)-2-oxoethyl)(2-methyl-2H-indazol-5-yl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | 86.56% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | 2-((2-((2-(ethylamino)ethyl)amino)-2-oxoethyl)(4-tolyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | 19.23% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | 2-((4-(1H-pyrrol-1-yl)phenyl)(2-((2-(diethylamino)-ethyl)amino)-2-oxoethyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | 20.16% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | 2-((4-(1H-pyrrol-1-yl)phenyl)(2-((2-(ethylamino)-ethyl)amino)-2-oxoethyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | 79.46% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | 2-((4-(1H-pyrrol-1-yl)phenyl)(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | 21.46% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | 2-((4-fluorophenyl)(2-oxo-2-((2-(piperidin-1-yl)ethyl)-amino)ethyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | 2.63% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | 3-deazaadenosine | 35.37% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | aristeromycin | 98.35% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | DZ2002 | - |
Mycobacterium tuberculosis | |
3.13.2.1 | N-(isoindolin-2-yl)-N-methyl-2-((1-methyl-1H-indazol-5-yl)(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)amino)-acetamide | 54.24% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | N-(isoindolin-2-yl)-N-methyl-2-((2-methyl-2H-indazol-5-yl)(2-oxo-2-((2-(piperidin-1-yl) ethyl)amino)ethyl)amino)-acetamide | 38.24% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | N-(isoindolin-2-yl)-N-methyl-2-((2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)(4-tolyl)amino)acetamide | 6.97% inhibition at 0.0025 mM | Mycobacterium tuberculosis | |
3.13.2.1 | neplanocin A | - |
Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.13.2.1 | S-adenosyl-L-homocysteine + H2O | Mycobacterium tuberculosis | - |
L-homocysteine + adenosine | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.13.2.1 | Mycobacterium tuberculosis | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.13.2.1 | S-adenosyl-L-homocysteine + H2O | - |
Mycobacterium tuberculosis | L-homocysteine + adenosine | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.13.2.1 | S-adenosyl-L-homocysteine hydrolase | - |
Mycobacterium tuberculosis |
3.13.2.1 | SAHase | - |
Mycobacterium tuberculosis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.13.2.1 | 0.00044 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((2-((2-(ethylamino)ethyl)amino)-2-oxoethyl)(2-methyl-2H-indazol-5-yl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | |
3.13.2.1 | 0.00048 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((2-((2-(ethylamino)ethyl)amino)-2-oxoethyl)(1-methyl-1H-indazol-5-yl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | |
3.13.2.1 | 0.00049 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | aristeromycin | |
3.13.2.1 | 0.00073 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((4-(1H-pyrrol-1-yl)phenyl)(2-((2-(ethylamino)-ethyl)amino)-2-oxoethyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | |
3.13.2.1 | 0.00203 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | N-(isoindolin-2-yl)-N-methyl-2-((1-methyl-1H-indazol-5-yl)(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)amino)-acetamide | |
3.13.2.1 | 0.00413 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | N-(isoindolin-2-yl)-N-methyl-2-((2-methyl-2H-indazol-5-yl)(2-oxo-2-((2-(piperidin-1-yl) ethyl)amino)ethyl)amino)-acetamide | |
3.13.2.1 | 0.00552 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | 3-deazaadenosine | |
3.13.2.1 | 0.00761 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((2-((2-(diethylamino)ethyl)amino)-2-oxoethyl)-(1-methyl-1H-indazol-5-yl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | |
3.13.2.1 | 0.01212 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((4-(1H-pyrrol-1-yl)phenyl)(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | |
3.13.2.1 | 0.01408 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((4-(1H-pyrrol-1-yl)phenyl)(2-((2-(diethylamino)-ethyl)amino)-2-oxoethyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | |
3.13.2.1 | 0.0156 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((2-((2-(ethylamino)ethyl)amino)-2-oxoethyl)(4-tolyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | |
3.13.2.1 | 0.02534 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((2-((2-(diethylamino)ethyl)amino)-2-oxoethyl)-(2-methyl-2H-indazol-5-yl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | |
3.13.2.1 | 0.07882 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((2-((2-(diethylamino)ethyl)amino)-2-oxoethyl)(4-fluorophenyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | |
3.13.2.1 | 0.1019 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | N-(isoindolin-2-yl)-N-methyl-2-((2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)(4-tolyl)amino)acetamide | |
3.13.2.1 | 0.214 | - |
at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((2-((2-(diethylamino)ethyl)amino)-2-oxoethyl)(4-tolyl)-amino)-N-(isoindolin-2-yl)-N-methylacetamide | |
3.13.2.1 | 0.5 | - |
IC50 above 0.5 mM, at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((2-((2-(diethylamino)ethyl)amino)-2-oxoethyl)(4-fluorophenyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide | |
3.13.2.1 | 0.5 | - |
IC50 above 0.5 mM, at pH 8.0 and 37°C | Mycobacterium tuberculosis | 2-((4-fluorophenyl)(2-oxo-2-((2-(piperidin-1-yl)ethyl)-amino)ethyl)amino)-N-(isoindolin-2-yl)-N-methylacetamide |