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Literature summary extracted from

  • Lu, E.P.; McLellan, M.; Ding, L.; Fulton, R.; Mardis, E.R.; Wilson, R.K.; Miller, C.A.; Westervelt, P.; DiPersio, J.F.; Link, D.C.; Walter, M.J.; Ley, T.J.; Graubert, T.A.
    Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice (2014), Blood, 124, 3887-3895.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.62 Mus musculus
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3.4.22.62 Mus musculus C57/BL6J
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.62 bone marrow cell
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 Mus musculus
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3.4.22.62 erythroid cell
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 Mus musculus
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3.4.22.62 lymphoid cell
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 Mus musculus
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3.4.22.62 myeloid cell
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 Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
3.4.22.62 casp9
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 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.22.62 malfunction loss of caspase-9 results in increased DNA damage and mutation burden after exposure to alkylating agents. Casp9 deficiency results in decreased erythroid and B-cell progenitor abundance and impaired function of hematopoietic stem cells after transplantation. Loss of Casp9 alters hematopoietic progenitor cell frequency Mus musculus
3.4.22.62 physiological function caspase-9 is required for normal development of myeloid, lymphoid, and erythroid cells in mice. Role of caspase-9, the initiator caspase of the intrinsic apoptotic cascade, in murine fetal and adult hematopoiesis, overview Mus musculus