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Literature summary extracted from

  • Yang, W.Y.; Won, T.H.; Ahn, C.H.; Lee, S.H.; Yang, H.C.; Shin, J.; Oh, K.B.
    Streptococcus mutans sortase A inhibitory metabolites from the flowers of Sophora japonica (2015), Bioorg. Med. Chem. Lett., 25, 1394-1397.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.70 4-hydroxymercuribenzoate
-
 Streptococcus mutans
3.4.22.70 curcumin
-
 Streptococcus mutans
3.4.22.70 isorhamnetin 3-O-beta-D-rutinoside
-
 Streptococcus mutans
3.4.22.70 kaempferol-3-rutinoside
-
 Streptococcus mutans
3.4.22.70 maltol 3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-beta-glucopyranoside
-
 Streptococcus mutans
3.4.22.70 maltol-3-O-(4'-O-cis-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-beta-glucopyranoside
-
 Streptococcus mutans
3.4.22.70 additional information sortase A inhibitory metabolites from the flowers of Sophora japonica, overview Streptococcus mutans

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.70 Streptococcus mutans
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.22.70 0.0586
-
 pH and temperature not specified in the publication Streptococcus mutans maltol-3-O-(4'-O-cis-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-beta-glucopyranoside
3.4.22.70 0.0607
-
 pH and temperature not specified in the publication Streptococcus mutans kaempferol-3-rutinoside
3.4.22.70 0.0621
-
 pH and temperature not specified in the publication Streptococcus mutans isorhamnetin 3-O-beta-D-rutinoside
3.4.22.70 0.0915
-
 pH and temperature not specified in the publication Streptococcus mutans curcumin
3.4.22.70 0.0943
-
 pH and temperature not specified in the publication Streptococcus mutans maltol 3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-beta-glucopyranoside
3.4.22.70 0.1125
-
 pH and temperature not specified in the publication Streptococcus mutans 4-hydroxymercuribenzoate