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Literature summary extracted from

  • Tanis, V.M.; Bacani, G.M.; Blevitt, J.M.; Chrovian, C.C.; Crawford, S.; De Leon, A.; Fourie, A.M.; Gomez, L.; Grice, C.A.; Herman, K.; Kearney, A.M.; Landry-Bayle, A.M.; Lee-Dutra, A.; Nelson, J.; Riley, J.P.; Santillan, A.; Wiener, J.J.; Xue, X.; Young, A.L.
    Azabenzthiazole inhibitors of leukotriene A4 hydrolase (2012), Bioorg. Med. Chem. Lett., 22, 7504-7511.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 1-(1-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenoxy]ethyl]piperidin-4-yl)pyrrolidin-2-one
-
 Homo sapiens
3.3.2.6 1-(1-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]piperidin-4-yl)pyrrolidin-2-one
-
 Homo sapiens
3.3.2.6 1-(5-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenoxy]ethyl]-2,5-diazabicyclo[2.2.1]hept-2-yl)ethanone
-
 Homo sapiens
3.3.2.6 1-(5-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]-2,5-diazabicyclo[2.2.1]hept-2-yl)ethanone
-
 Homo sapiens
3.3.2.6 1-[1-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzyl]piperidin-4-yl]pyrrolidin-2-one
-
 Homo sapiens
3.3.2.6 1-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenoxy]ethyl]piperidine-4-carboxamide
-
 Homo sapiens
3.3.2.6 1-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]piperidine-4-carboxamide
-
 Homo sapiens
3.3.2.6 1-[4-(1,3-benzothiazol-2-yloxy)benzyl]piperidine-4-carboxamide
-
 Homo sapiens
3.3.2.6 1-[4-(1,3-benzothiazol-2-yloxy)benzyl]piperidine-4-carboxylic acid
-
 Homo sapiens
3.3.2.6 1-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzyl]piperidine-4-carboxamide
-
 Homo sapiens
3.3.2.6 1-[4-([1,3]thiazolo[5,4-b]pyridin-2-yloxy)benzyl]piperidine-4-carboxamide
-
 Homo sapiens
3.3.2.6 1-[5-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenoxy]ethyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]ethanone
-
 Homo sapiens
3.3.2.6 1-[5-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]ethanone
-
 Homo sapiens
3.3.2.6 1-[5-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]ethanone
-
 Homo sapiens
3.3.2.6 1-[5-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]ethanone
-
 Homo sapiens
3.3.2.6 2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[4,5-b]pyridine
-
 Homo sapiens
3.3.2.6 2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[4,5-c]pyridine
-
 Homo sapiens
3.3.2.6 2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[5,4-c]pyridine
-
 Homo sapiens
3.3.2.6 2-[4-[2-(piperidin-1-yl)ethoxy]phenoxy][1,3]thiazolo[4,5-b]pyridine
-
 Homo sapiens
3.3.2.6 2-[4-[2-(piperidin-1-yl)ethyl]phenoxy][1,3]thiazolo[4,5-b]pyridine
-
 Homo sapiens
3.3.2.6 6-chloro-2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[4,5-b]pyridine
-
 Homo sapiens
3.3.2.6 6-fluoro-2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[4,5-b]pyridine
-
 Homo sapiens
3.3.2.6 7-methyl-2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[4,5-b]pyridine
-
 Homo sapiens
3.3.2.6 N-(8-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenoxy]ethyl]-8-azabicyclo[3.2.1]oct-3-yl)acetamide
-
 Homo sapiens
3.3.2.6 N-(8-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]-8-azabicyclo[3.2.1]oct-3-yl)acetamide
-
 Homo sapiens
3.3.2.6 N-[1-[4-(1,3-benzothiazol-2-yloxy)benzyl]piperidin-4-yl]-2-hydroxyacetamide
-
 Homo sapiens
3.3.2.6 N-[8-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzyl]-8-azabicyclo[3.2.1]oct-3-yl]acetamide
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.6 cytosol
-
 Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.3.2.6 Zn2+ contains zinc Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens
-
 leukotriene B4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene A4 hydrolase
-
 Homo sapiens
3.3.2.6 LTA4H
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.3.2.6 0.0000003
-
 pH and temperature not specified in the publication Homo sapiens N-(8-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]-8-azabicyclo[3.2.1]oct-3-yl)acetamide
3.3.2.6 0.000003
-
 pH and temperature not specified in the publication Homo sapiens 2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[4,5-b]pyridine
3.3.2.6 0.000003
-
 pH and temperature not specified in the publication Homo sapiens 2-[4-[2-(piperidin-1-yl)ethyl]phenoxy][1,3]thiazolo[4,5-b]pyridine
3.3.2.6 0.000004
-
 pH and temperature not specified in the publication Homo sapiens N-(8-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenoxy]ethyl]-8-azabicyclo[3.2.1]oct-3-yl)acetamide
3.3.2.6 0.000006
-
 pH and temperature not specified in the publication Homo sapiens 1-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzyl]piperidine-4-carboxamide
3.3.2.6 0.000006
-
 pH and temperature not specified in the publication Homo sapiens 1-(1-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenoxy]ethyl]piperidin-4-yl)pyrrolidin-2-one
3.3.2.6 0.000006
-
 pH and temperature not specified in the publication Homo sapiens 1-[5-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]ethanone
3.3.2.6 0.000007
-
 pH and temperature not specified in the publication Homo sapiens 1-[5-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenoxy]ethyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]ethanone
3.3.2.6 0.000007
-
 pH and temperature not specified in the publication Homo sapiens 1-(5-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenoxy]ethyl]-2,5-diazabicyclo[2.2.1]hept-2-yl)ethanone
3.3.2.6 0.000008
-
 pH and temperature not specified in the publication Homo sapiens 2-[4-[2-(piperidin-1-yl)ethoxy]phenoxy][1,3]thiazolo[4,5-b]pyridine
3.3.2.6 0.000011
-
 pH and temperature not specified in the publication Homo sapiens 1-[4-(1,3-benzothiazol-2-yloxy)benzyl]piperidine-4-carboxylic acid
3.3.2.6 0.000011
-
 pH and temperature not specified in the publication Homo sapiens 1-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]piperidine-4-carboxamide
3.3.2.6 0.000013
-
 pH and temperature not specified in the publication Homo sapiens N-[1-[4-(1,3-benzothiazol-2-yloxy)benzyl]piperidin-4-yl]-2-hydroxyacetamide
3.3.2.6 0.000014
-
 pH and temperature not specified in the publication Homo sapiens 1-(1-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]piperidin-4-yl)pyrrolidin-2-one
3.3.2.6 0.000014
-
 pH and temperature not specified in the publication Homo sapiens 1-(5-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl]-2,5-diazabicyclo[2.2.1]hept-2-yl)ethanone
3.3.2.6 0.000016
-
 pH and temperature not specified in the publication Homo sapiens 1-[2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenoxy]ethyl]piperidine-4-carboxamide
3.3.2.6 0.000017
-
 pH and temperature not specified in the publication Homo sapiens 1-[4-(1,3-benzothiazol-2-yloxy)benzyl]piperidine-4-carboxamide
3.3.2.6 0.000029
-
 pH and temperature not specified in the publication Homo sapiens 6-fluoro-2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[4,5-b]pyridine
3.3.2.6 0.00003
-
 pH and temperature not specified in the publication Homo sapiens 1-[5-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]ethanone
3.3.2.6 0.000033
-
 pH and temperature not specified in the publication Homo sapiens 7-methyl-2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[4,5-b]pyridine
3.3.2.6 0.00004
-
 pH and temperature not specified in the publication Homo sapiens 6-chloro-2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[4,5-b]pyridine
3.3.2.6 0.000049
-
 pH and temperature not specified in the publication Homo sapiens 1-[1-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzyl]piperidin-4-yl]pyrrolidin-2-one
3.3.2.6 0.000053
-
 pH and temperature not specified in the publication Homo sapiens 1-[5-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]ethanone
3.3.2.6 0.000083
-
 pH and temperature not specified in the publication Homo sapiens N-[8-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzyl]-8-azabicyclo[3.2.1]oct-3-yl]acetamide
3.3.2.6 0.000614
-
 pH and temperature not specified in the publication Homo sapiens 2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[5,4-c]pyridine
3.3.2.6 0.000733
-
 pH and temperature not specified in the publication Homo sapiens 1-[4-([1,3]thiazolo[5,4-b]pyridin-2-yloxy)benzyl]piperidine-4-carboxamide
3.3.2.6 0.0018
-
 pH and temperature not specified in the publication Homo sapiens 2-[4-(piperidin-1-ylmethyl)phenoxy][1,3]thiazolo[4,5-c]pyridine