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Literature summary extracted from

  • Liu, X.; Chen, Q.; Zhu, J.; Fan, Y.; Ding, L.; Zhao, J.; Han, G.; Tian, W.; Qi, J.; Zhou, Y.; Lv, J.
    Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H-benzo[d]imidazol-2-yl carbamate derivatives (2012), Bioorg. Med. Chem. Lett., 22, 3554-3559.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.10 5-(2,4-dichlorophenyl)-1,2-oxazole-3-carbaldehyde
-
 Homo sapiens
3.4.21.10 DV-1006
-
 Homo sapiens
3.4.21.10 KF950
-
 Homo sapiens
3.4.21.10 methyl (6-[[4-(trifluoromethyl)phenyl]sulfamoyl]-1H-benzimidazol-2-yl)carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-(butylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-(hexylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-(phenylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-(propan-2-ylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(2,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(2,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(2,5-dimethylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(2-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(2-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(2-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(3,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(3,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(3,4-dimethoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(3-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(3-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(3-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(4-bromophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(4-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(4-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(4-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[(4-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[benzyl(methyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 methyl [6-[bis(3-methylbutyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
 Homo sapiens
3.4.21.10 N-alpha-tosyl-L-lysyl-chloromethyl-ketone
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.10 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.10 Nalpha-benzoyl-L-arginine 4-nitroanilide + H2O
-
 Homo sapiens Nalpha-benzoyl-L-arginine + 4-nitroaniline
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.10 0.063
-
 pH 8.0, 22°C Homo sapiens methyl [6-[bis(3-methylbutyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 0.31
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(2-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 0.47
-
 pH 8.0, 22°C Homo sapiens methyl [6-(propan-2-ylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
3.4.21.10 1.03
-
 pH 8.0, 22°C Homo sapiens methyl [6-(phenylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
3.4.21.10 1.25
-
 pH 8.0, 22°C Homo sapiens methyl [6-[benzyl(methyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 1.27
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(2,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 1.55
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(2,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 1.59
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(3,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 1.64
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(4-bromophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 1.7
-
 pH 8.0, 22°C Homo sapiens 5-(2,4-dichlorophenyl)-1,2-oxazole-3-carbaldehyde
3.4.21.10 1.77
-
 pH 8.0, 22°C Homo sapiens methyl [6-(butylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
3.4.21.10 1.8
-
 pH 8.0, 22°C Homo sapiens methyl [6-(hexylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
3.4.21.10 1.81
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(3-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 2.4
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(4-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 3.18
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(4-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 3.29
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(4-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 4.02
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(3,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 5.06
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(3-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 5.75
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(2-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 7.5
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(3-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 7.52
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(4-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 8.42
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(2-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 8.86
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(2,5-dimethylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.4.21.10 10.7
-
 pH 8.0, 22°C Homo sapiens methyl (6-[[4-(trifluoromethyl)phenyl]sulfamoyl]-1H-benzimidazol-2-yl)carbamate
3.4.21.10 11.5
-
 pH 8.0, 22°C Homo sapiens methyl [6-[(3,4-dimethoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate