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Literature summary extracted from

  • Achour, O.; Bridiau, N.; Kacem, M.; Delatouche, R.; Bordenave-Juchereau, S.; Sannier, F.; Thiery, V.; Piot, J.M.; Maugard, T.; Arnaudin, I.
    Cathepsin D activity and selectivity in the acidic conditions of a tumor microenvironment: Utilization in the development of a novel cathepsin D substrate for simultaneous cancer diagnosis and therapy (2013), Biochimie, 95, 2010-2017.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.23.5 0.0211
-
 R[K-2,4-dinitrophenyl]LRFFLIPK[G-7-amido-4-methylcoumarin] at pH 3.7 and 37°C Homo sapiens
3.4.23.5 0.0741
-
 [aminooxy-acetyl-K]LLVVFF[D-PEG2] at pH 3.7 and 37°C Homo sapiens
3.4.23.5 0.1933
-
 LLVVFF at pH 3.7 and 37°C Homo sapiens
3.4.23.5 0.394
-
 LLVVYPWTQRFF at pH 3.7 and 37°C Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.23.5 14000
-
 1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE Homo sapiens
3.4.23.5 34000
-
 1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE Homo sapiens
3.4.23.5 52000
-
 x * 52000, pro-cathepsin D, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.5 Hemoglobin + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.5 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.5 Hemoglobin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 LLVVFF + H2O
-
 Homo sapiens LVVFF + VVFF + LLVVF + LVVF + VVF + Leu-Leu + Phe
-
 ?
3.4.23.5 LLVVYPWTQRFF + H2O cleavage occurs at the C-terminus (F-F) and the N-terminus (L-L, L-V and LL-V) Homo sapiens LVVYPWTQRFF + VVYPWTQRFF + LLVVYPWTQRF + LVVYPWTQRF + VVYPWTQRF + Leu-Leu + Phe
-
 ?
3.4.23.5 additional information does not hydrolyze KLLVVFFD Homo sapiens ?
-
 ?
3.4.23.5 additional information the proenzyme can auto activate and cleave its substrates at an acidic pH Homo sapiens ?
-
 ?
3.4.23.5 R[K-2,4-dinitrophenyl]LRFFLIPK[G-7-amido-4-methylcoumarin] + H2O
-
 Homo sapiens R[K-2,4-dinitrophenyl]LRF + FLIPK[G-7-amido-4-methylcoumarin]
-
 ?
3.4.23.5 [aminooxy-acetyl-K]LLVVFF[D-PEG2] + H2O the proform of cathepsin D cleaves the substrate at pH 6.5 with the same cleavage selectivity obtained with the mature form of the protease Homo sapiens [aminooxy-acetyl-K]LL + VVF + VVFF[D-PEG2] + F[D-PEG2]
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.23.5 ? x * 52000, pro-cathepsin D, SDS-PAGE Homo sapiens
3.4.23.5 heterodimer 1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.23.5 PCD
-
 Homo sapiens
3.4.23.5 pro-cathepsin D
-
 Homo sapiens