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Literature summary extracted from

  • Krstic, J.; Obradovic, H.; Jaukovic, A.; Okic-Dordevic, I.; Trivanovic, D.; Kukolj, T.; Mojsilovic, S.; Ilic, V.; Santibanez, J.F.; Bugarski, D.
    Urokinase type plasminogen activator mediates interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration (2015), Biochim. Biophys. Acta, 1853, 431-444.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens P00749
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 mesenchymal stem cell
-
 Homo sapiens
-
3.4.21.73 PC-3 cell
-
 Homo sapiens
-
3.4.21.73 peripheral blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 casein + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.73 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 uPA
-
 Homo sapiens
3.4.21.73 urokinase type plasminogen activator
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.73 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.73 7.4
-
 assay at Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.73 Homo sapiens interleukin-17 induces enzyme production in peripheral blood mesenchymal stem cells, without affecting matrix metalloproteinase expression up

General Information

EC Number General Information Comment Organism
3.4.21.73 physiological function the enzyme mediates interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration without affecting matrix metalloproteinase expression, detailed overview. Interleukin-17 increases peripheral blood mesenchymal stem cell adhesion to endothelial cells and transendothelial migration, as well as increases the capacity of cell adhesion to fibronectin, in an urokinase-tyype plasminogen activator-dependent fashion Homo sapiens