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Literature summary extracted from

  • Smith, M.; Schnellmann, R.
    Mitochondrial calpain 10 is degraded by Lon protease after oxidant injury (2012), Arch. Biochem. Biophys., 517, 144-152.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.53 H2O2 activation is not inhibited by MG132 Oryctolagus cuniculus
3.4.21.53 tert-butyl hydroperoxide activation is inhibited by MG132 Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.53 MG132 causes calpain 10 accumulation in vivo Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.53 mitochondrion
-
 Oryctolagus cuniculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.53 calpain 10 + H2O Oryctolagus cuniculus degradation of the mitochondrial matrix protease ?
-
 ?
3.4.21.53 calpain 10 + H2O Oryctolagus cuniculus New Zealand White degradation of the mitochondrial matrix protease ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.53 Oryctolagus cuniculus
-
-
-
3.4.21.53 Oryctolagus cuniculus New Zealand White
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.53 renal cortex
-
 Oryctolagus cuniculus
-
3.4.21.53 renal proximal tubule
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.53 calpain 10 + H2O
-
 Oryctolagus cuniculus ?
-
 ?
3.4.21.53 calpain 10 + H2O degradation of the mitochondrial matrix protease Oryctolagus cuniculus ?
-
 ?
3.4.21.53 calpain 10 + H2O
-
 Oryctolagus cuniculus New Zealand White ?
-
 ?
3.4.21.53 calpain 10 + H2O degradation of the mitochondrial matrix protease Oryctolagus cuniculus New Zealand White ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.53 lon protease
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.53 37
-
 assay at, in vivo Oryctolagus cuniculus

General Information

EC Number General Information Comment Organism
3.4.21.53 metabolism mitochondrial calpain 10 is selectively degraded by Lon protease under basal conditions and is enhanced under and oxidizing conditions, while cytosolic calpain 10 is degraded by the proteasome Oryctolagus cuniculus