Literature summary extracted from

Smith, P.A.; Romesberg, F.E.
Mechanism of action of the arylomycin antibiotics and effects of signal peptidase I inhibition (2012), Antimicrob. Agents Chemother., 56, 5054-5060.

Application

EC Number	Application	Comment	Organism
3.4.21.89	medicine	inhibition of enzyme by arylomycin A-C16 results in an insufficient flux of proteins through the secretion pathway leading to mislocalization of proteins. Inhibition results in synergistic sensitivity of cells when combined with an aminoglycoside. Antibiotics tetracycline, erythromycin, and vancomycin each interact additively with arylomycin A-C16, while rifampin and trimethoprim show pronounced antagonism	Staphylococcus aureus
3.4.21.89	medicine	inhibition of enzyme by arylomycin A-C16 results in an insufficient flux of proteins through the secretion pathway leading to mislocalization of proteins. Inhibition results in synergistic sensitivity of cells when combined with an aminoglycoside. No significant interactions are observed between arylomycin A-C16 and erythromycin, polymyxin B, trimethoprim, or ciprofloxacin. Arylomycin A-C16 shows mild synergism with cephalexin, pronounced synergism with rifampin and gentamicin, and antagonism with the translational inhibitor tetracycline	Escherichia coli

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.89	arylomycin A-C16	inhibition of enzyme results in an insufficient flux of proteins through the secretion pathway leading to mislocalization of proteins. Inhibition results in synergistic sensitivity when combined with an aminoglycoside	Escherichia coli
3.4.21.89	arylomycin A-C16	inhibition of enzyme results in an insufficient flux of proteins through the secretion pathway leading to mislocalization of proteins. Inhibition results in synergistic sensitivity when combined with an aminoglycoside	Staphylococcus aureus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.89	Escherichia coli	-	-	-
3.4.21.89	Staphylococcus aureus	-	-	-

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Release 2023.1 (January 2023)