EC Number | Application | Comment | Organism |
---|---|---|---|
3.1.1.31 | drug development | the enzyme is a target for anti-parasite drug development | Trypanosoma brucei |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.1.31 | glycosome | - |
Trypanosoma brucei | 20015 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.31 | 6-phospho-D-glucono-1,5-lactone + H2O | Trypanosoma brucei | - |
6-phospho-D-gluconate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.31 | Trypanosoma brucei | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.31 | 6-phospho-D-glucono-1,5-lactone + H2O | - |
Trypanosoma brucei | 6-phospho-D-gluconate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.31 | 6PGL | - |
Trypanosoma brucei |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.1.31 | metabolism | the enzyme is one of the six enzymes of the pentose phosphate pathway of Trypanosoma brucei and hydrolyzes D-6-phosphogluconolactone to 6-phosphogluconic acid | Trypanosoma brucei |
3.1.1.31 | additional information | analysis of effects of ligand binding on the internal dynamics of the enzyme by molecular dynamics simulations and nuclear magnetic resonance, alterations of conformational exchange, overview. Residues R77 and R200, located near the active site, interact directly with the phosphate group of 6-phospho-D-gluconate. Residue H165 is actively involved in catalysis | Trypanosoma brucei |
3.1.1.31 | physiological function | the enzyme plays a key role during infection, by providing the important reductive agent NADPH, and forms ribose 5-phosphate, a major nucleic acid precursor, as well as several metabolic intermediates, such as fructose 6-phosphate and glyceraldehyde 3-phosphate | Trypanosoma brucei |