Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yang, C.; Swallows, C.L.; Zhang, C.; Lu, J.; Xiao, H.; Brady, R.O.; Zhuang, Z.
    Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones (2014), Proc. Natl. Acad. Sci. USA, 111, 249-254.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.45 celastrol significantly increases the quantity and catalytic activity of the enzyme by reducing protein degradation Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.2.1.45 L444P the mutant shows strongly reduced activity Homo sapiens
3.2.1.45 N370S the mutant shows reduced activity Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.45 glucocerebroside + H2O Homo sapiens
-
 ceramide + D-glucose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.45 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.45 glucocerebroside + H2O
-
 Homo sapiens ceramide + D-glucose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.45 Gcase
-
 Homo sapiens
3.2.1.45 glucocerebrosidase
-
 Homo sapiens