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Literature summary extracted from
- Neuroprotection and repair of 3-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1) (2014), Proc. Natl. Acad. Sci. USA, 111, 15816-15820.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.4.1 | gene gkt, DNA and amino acid sequence determination and analysis | Drosophila melanogaster |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.1.4.1 | additional information | homozygous PiggyBac insertion, c03958, disrupts the 5'-UTR of gene gkt resulting in mutant flies that are defective in hydrolyzing 3'-DNA-tyrosyl residues. The phenotype iss rescued by neuronal expression of the enzyme TDP1 | Drosophila melanogaster |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.1 | Drosophila melanogaster | - |
gene glaikit or gkt | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.1 | TDP1 | - |
Drosophila melanogaster |
| 3.1.4.1 | tyrosyl-DNA phosphodiesterase 1 | - |
Drosophila melanogaster |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.4.1 | evolution | the enzyme is phylogenetically conserved | Drosophila melanogaster |
| 3.1.4.1 | malfunction | the c03958 insertion gene gkt disruption mutant of TDP1 is generally healthy and fertile, but females exhibit reduced lifespan and diminished climbing ability. Insertion mutant c03958 larvae are exposed to bleomycin, an agent that produces oxidative DNA damage, or topoisomerase I-targeted drugs (camptothecin and a noncamptothecin indenoisoquinoline derivative, LMP-776), survivors display rough eye patches, which are rescued by neuronal expression of wild-type enzyme TDP1, overview | Drosophila melanogaster |
| 3.1.4.1 | physiological function | the enzyme is critical for neuroprotection, normal longevity, and repair of damaged DNA through the removal of blocking lesions at the 3'-ends of DNA or RNA | Drosophila melanogaster |
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