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Literature summary extracted from

  • Stock, R.P.; Brewer, J.; Wagner, K.; Ramos-Cerrillo, B.; Duelund, L.; Jernsh?j, K.D.; Olsen, L.F.; Bagatolli, L.A.
    Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate (2012), PLoS ONE, 7, e36003.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.41 additional information
-
 additional information kinetics of enzyme activity on large unilamellar vesicles, overview Loxosceles laeta

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.41 extracellular
-
 Loxosceles laeta
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.41 Mg2+ required Loxosceles laeta

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.41 N-lauroyl-D-erythro-sphingosylphosphorylcholine + H2O Loxosceles laeta
-
 lauroyl ceramide-1-phosphate + choline
-
 ?
3.1.4.41 sphingomyelin + H2O Loxosceles laeta
-
 ceramide phosphate + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.41 Loxosceles laeta
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.41 venom
-
 Loxosceles laeta
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.41 N-lauroyl-D-erythro-sphingosylphosphorylcholine + H2O
-
 Loxosceles laeta lauroyl ceramide-1-phosphate + choline
-
 ?
3.1.4.41 sphingomyelin + H2O
-
 Loxosceles laeta ceramide phosphate + choline
-
 ?
3.1.4.41 sphingomyelin + H2O from egg yolk Loxosceles laeta ceramide phosphate + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.41 SMD
-
 Loxosceles laeta
3.1.4.41 sphingomyelinase D
-
 Loxosceles laeta

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.41 22
-
 assay at Loxosceles laeta

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.41 7.4
-
 assay at Loxosceles laeta

General Information

EC Number General Information Comment Organism
3.1.4.41 physiological function the activity of sphingomyelinase D is clearly influenced by the supramolecular organization of its substrate in membranes and, in situ ceramide-1-phosphate generation by enzymatic activity profoundly alters the lateral structure and morphology of the target membranes Loxosceles laeta