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Literature summary extracted from
- Structural insights into cholinesterases inhibition by harmane beta-carbolinium derivatives: A kinetics-molecular modeling approach (2012), Phytochemistry, 81, 24-30.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.8 | 1,2-dimethyl-beta-carbolin-2-ium iodide | noncompetitive inhibition | Equus caballus |  |
| 3.1.1.8 | 2-ethyl-1-methyl-beta-carbolin-2-ium iodide | noncompetitive inhibition | Equus caballus | |
| 3.1.1.8 | 6-chloro-2-methyl-9H-beta-carbolin-2-ium iodide | - |
Equus caballus | |
| 3.1.1.8 | 6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium iodide | - |
Equus caballus | |
| 3.1.1.8 | galantamine | - |
Equus caballus | |
| 3.1.1.8 | Harmane | noncompetitive inhibition | Equus caballus | |
| 3.1.1.8 | physostigmine | - |
Equus caballus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.8 | Equus caballus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.8 | serum | - |
Equus caballus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.8 | butyrylthiocholine + H2O | - |
Equus caballus | butyrate + thiocholine | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.8 | BChE | - |
Equus caballus |
| 3.1.1.8 | butyrylcholinesterase | - |
Equus caballus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.8 | 0.00023 | - |
1,2-dimethyl-beta-carbolin-2-ium iodide | pH and temperature not specified in the publication | Equus caballus | |
| 3.1.1.8 | 0.000637 | - |
2-ethyl-1-methyl-beta-carbolin-2-ium iodide | pH and temperature not specified in the publication | Equus caballus | |
| 3.1.1.8 | 0.09 | - |
Harmane | pH and temperature not specified in the publication | Equus caballus | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.8 | 0.00023 | - |
pH and temperature not specified in the publication | Equus caballus | 1,2-dimethyl-beta-carbolin-2-ium iodide | |
| 3.1.1.8 | 0.000637 | - |
pH and temperature not specified in the publication | Equus caballus | 2-ethyl-1-methyl-beta-carbolin-2-ium iodide | |
| 3.1.1.8 | 0.0012 | - |
pH and temperature not specified in the publication | Equus caballus | 6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium iodide | |
| 3.1.1.8 | 0.0037 | - |
pH and temperature not specified in the publication | Equus caballus | physostigmine | |
| 3.1.1.8 | 0.0132 | - |
pH and temperature not specified in the publication | Equus caballus | 6-chloro-2-methyl-9H-beta-carbolin-2-ium iodide | |
| 3.1.1.8 | 0.09 | - |
pH and temperature not specified in the publication | Equus caballus | Harmane | |
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