EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.46 | glycerophosphocholine + H2O | Homo sapiens | - |
choline + glycerol-3-phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.46 | Homo sapiens | Q8WTR4 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.46 | breast cancer cell | the isozyme GDPD5 is significantly overexpressed in highly malignant estrogen receptor negative compared to weakly malignant estrogen receptor positive human breast cancer cells and breast tumors from patients, GDPD5 expression in tumors and correlation to choline containing metabolite levels, overview | Homo sapiens | - |
3.1.4.46 | MCF-12A cell | nonmalignant human mammary epithelial cells | Homo sapiens | - |
3.1.4.46 | MCF-7 cell | estrogen-sensitive weakly metastatic human breast cancer cells | Homo sapiens | - |
3.1.4.46 | MDA-MB-231 cell | estrogen-independent highly metastatic human breast cancer cells | Homo sapiens | - |
3.1.4.46 | additional information | isozyme GDPD5 is ubiquitously expressed in human tissues | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.46 | glycerophosphocholine + H2O | - |
Homo sapiens | choline + glycerol-3-phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.46 | GDPD5 | - |
Homo sapiens |
3.1.4.46 | glycerophosphodiester phosphodiesterase domain containing 5 | - |
Homo sapiens |
3.1.4.46 | GPC-PDE | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.4.46 | evolution | the human glycerophosphodiester phosphodiesterase domain (GDPD) containing family consists of 5 isozymes, GDPD1-5 | Homo sapiens |
3.1.4.46 | malfunction | the enzyme encoded by glycerophosphodiester phosphodiesterase domain containing 5 is associated with breast cancer malignancy | Homo sapiens |
3.1.4.46 | metabolism | the isozyme GDPD5 is a glycerophosphodiester phosphodiesterase that likely participates in regulating choline phospholipid metabolism in breast cancer, which possibly occurs in cooperation with choline kinase alpha and phosphatidylcholine-specific phospholipase D1 | Homo sapiens |