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Literature summary extracted from
- Diethyl 2-(phenylcarbamoyl)phenyl phosphorothioates: synthesis, antimycobacterial activity and cholinesterase inhibition (2014), Molecules, 19, 7152-7168.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.8 | galanthamine | - |
Equus caballus |  |
| 3.1.1.8 | O-(4-bromo-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-(4-bromo-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | least effective inhibitor | Equus caballus | |
| 3.1.1.8 | O-(4-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-(4-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-(5-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-(5-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[2-[(3-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[2-[(3-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[2-[(4-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[2-[(4-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-bromo-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-bromo-2-[(3-bromophenyl)carbamoyl]phenyl] diethyl phosphate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-bromo-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-bromo-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-bromo-2-[(4-bromophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-bromo-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-bromo-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[4-chloro-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[5-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[5-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | second best inhibitor | Equus caballus | |
| 3.1.1.8 | O-[5-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | - |
Equus caballus | |
| 3.1.1.8 | O-[5-chloro-2-[(4-fluorophenyl)-carbamoyl]phenyl] O,O-diethyl phosphorothioate | most efficient inhibitor | Equus caballus | |
| 3.1.1.8 | rivastigmine | - |
Equus caballus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.8 | Equus caballus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.8 | serum | - |
Equus caballus | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.8 | BChE | - |
Equus caballus |
| 3.1.1.8 | butyrylcholinesterase | - |
Equus caballus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.8 | 0.00796 | - |
pH and temperature not specified in the publication | Equus caballus | galanthamine | |
| 3.1.1.8 | 0.00867 | - |
pH and temperature not specified in the publication | Equus caballus | O-[5-chloro-2-[(4-fluorophenyl)-carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.00868 | - |
pH and temperature not specified in the publication | Equus caballus | O-[5-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0118 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0122 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-bromo-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0125 | - |
pH and temperature not specified in the publication | Equus caballus | O-[5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0126 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-bromo-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0127 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0135 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-bromo-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0138 | - |
pH and temperature not specified in the publication | Equus caballus | O-[5-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0139 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-bromo-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0147 | - |
pH and temperature not specified in the publication | Equus caballus | O-[5-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0148 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0149 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-chloro-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0149 | - |
pH and temperature not specified in the publication | Equus caballus | O-[2-[(3-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.015 | - |
pH and temperature not specified in the publication | Equus caballus | O-(5-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0151 | - |
pH and temperature not specified in the publication | Equus caballus | O-[2-[(3-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0151 | - |
pH and temperature not specified in the publication | Equus caballus | O-[2-[(4-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0156 | - |
pH and temperature not specified in the publication | Equus caballus | O-(4-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0164 | - |
pH and temperature not specified in the publication | Equus caballus | O-[2-[(4-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0174 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0183 | - |
pH and temperature not specified in the publication | Equus caballus | O-(5-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0188 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-bromo-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0189 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-bromo-2-[(4-bromophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0199 | - |
pH and temperature not specified in the publication | Equus caballus | O-(4-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.01995 | - |
pH and temperature not specified in the publication | Equus caballus | rivastigmine | |
| 3.1.1.8 | 0.02 | - |
pH and temperature not specified in the publication | Equus caballus | O-[4-bromo-2-[(3-bromophenyl)carbamoyl]phenyl] diethyl phosphate | |
| 3.1.1.8 | 0.02 | - |
pH and temperature not specified in the publication | Equus caballus | O-(4-bromo-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | |
| 3.1.1.8 | 0.0202 | - |
pH and temperature not specified in the publication | Equus caballus | O-(4-bromo-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate | |
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