EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.23 | [4-[bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone | a highly potent selective inhibitor | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.23 | 0.0097 | - |
2-arachidonoylglycerol | at pH 7.4 and 37°C | Homo sapiens | |
3.1.1.23 | 0.0122 | - |
2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol | at pH 7.4 and 37°C | Homo sapiens | |
3.1.1.23 | 0.02 | - |
1-decanoyl-rac-glycerol | at pH 7.4 and 37°C | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.1.1.23 | 33000 | - |
x * 33000, SDS-PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.23 | 1-arachidonoylglycerol + H2O | Homo sapiens | best substrate | glycerol + arachidonic acid | - |
? | |
3.1.1.23 | 2-arachidonoylglycerol + H2O | Homo sapiens | - |
glycerol + arachidonic acid | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.23 | Homo sapiens | Q99685 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.23 | HEK-293 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.23 | 1-arachidonoylglycerol + H2O | best substrate | Homo sapiens | glycerol + arachidonic acid | - |
? | |
3.1.1.23 | 1-decanoyl-rac-glycerol + H2O | - |
Homo sapiens | glycerol + decanoic acid | - |
? | |
3.1.1.23 | 2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol + H2O | highest preference | Homo sapiens | ? | - |
? | |
3.1.1.23 | 2-arachidonoylglycerol + H2O | - |
Homo sapiens | glycerol + arachidonic acid | - |
? | |
3.1.1.23 | prostaglandin D2-glycerol + H2O | - |
Homo sapiens | ? | - |
? | |
3.1.1.23 | prostaglandin E2-glycerol + H2O | - |
Homo sapiens | ? | - |
? | |
3.1.1.23 | prostaglandin F2alpha-glycerol + H2O | - |
Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.1.23 | ? | x * 33000, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.23 | MAGL | - |
Homo sapiens |
3.1.1.23 | monoacylglycerol lipase | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.1.1.23 | 0.0000002 | - |
at pH 7.4 and 37°C | Homo sapiens | [4-[bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone |