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Literature summary extracted from

  • Laitinen, T.; Navia-Paldanius, D.; Rytilahti, R.; Marjamaa, J.J.; Ka?izkova, J.; Parkkari, T.; Pantsar, T.; Poso, A.; Laitinen, J.T.; Savinainen, J.R.
    Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency (2014), Mol. Pharmacol., 85, 510-519.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.23 expressed in HEK-293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.23 C201A the mutation causes a significant reduction in overall activity particularly skewing the balanced hydrolysis of monoacyl glycerol isomers to favor the 2-isomer over the 1-isomer Homo sapiens
3.1.1.23 C208A the mutation causes a significant reduction in overall activity particularly skewing the balanced hydrolysis of monoacyl glycerol isomers to favor the 2-isomer over the 1-isomer Homo sapiens
3.1.1.23 C242A the mutation causes a significant reduction in overall activity particularly skewing the balanced hydrolysis of monoacyl glycerol isomers to favor the 2-isomer over the 1-isomer Homo sapiens
3.1.1.23 Y194A the mutation causes a significant reduction in overall activity Homo sapiens
3.1.1.23 Y194A/C242A the mutation causes a significant reduction in overall activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.23 isopropyldodecylfluorophosphonate
-
 Homo sapiens
3.1.1.23 JJKK-048 i.e. 4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone Homo sapiens
3.1.1.23 JZL184 i.e. 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate Homo sapiens
3.1.1.23 methylarachidonoylfluorophosphonate
-
 Homo sapiens
3.1.1.23 N-arachidonoylmaleimide
-
 Homo sapiens
3.1.1.23 pristimerin
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.23 0.01
-
 2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol mutant enzyme C242A, at pH 7.4 and 37°C Homo sapiens
3.1.1.23 0.013
-
 2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol mutant enzyme C201A, at pH 7.4 and 37°C Homo sapiens
3.1.1.23 0.015
-
 2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol wild type enzyme, at pH 7.4 and 37°C Homo sapiens
3.1.1.23 0.016
-
 2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol mutant enzyme C208A, at pH 7.4 and 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 1-arachidonoylglycerol + H2O
-
 Homo sapiens glycerol + arachidonic acid
-
 ?
3.1.1.23 1-capryloyl-rac-glycerol + H2O
-
 Homo sapiens glycerol + caprylic acid
-
 ?
3.1.1.23 1-decanoyl-rac-glycerol + H2O best substrate Homo sapiens glycerol + decanoic acid
-
 ?
3.1.1.23 1-lauroyl-rac-glycerol + H2O
-
 Homo sapiens glycerol + lauric acid
-
 ?
3.1.1.23 1-linoleoylglycerol + H2O
-
 Homo sapiens glycerol + linoleic acid
-
 ?
3.1.1.23 1-myristoyl-rac-glycerol + H2O
-
 Homo sapiens glycerol + myristic acid
-
 ?
3.1.1.23 2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.23 2-arachidonoylglycerol + H2O
-
 Homo sapiens glycerol + arachidonic acid
-
 ?
3.1.1.23 2-linoleoylglycerol + H2O
-
 Homo sapiens glycerol + linoleic acid
-
 ?
3.1.1.23 2-palmitoylglycerol + H2O
-
 Homo sapiens glycerol + palmitic acid
-
 ?
3.1.1.23 prostaglandin D2-glycerol + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.23 prostaglandin E2-glycerol + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 MGL
-
 Homo sapiens
3.1.1.23 monoacylglycerol lipase
-
 Homo sapiens