EC Number | Cloned (Comment) | Organism |
---|---|---|
3.2.1.18 | expressed in Escherichia coli BL21 Star (DE3) cells | Treponema denticola |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.2.1.18 | 0.0187 | - |
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid | in 70 mM sodium citrate, at pH 7.0 and 37°C | Treponema denticola |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.2.1.18 | cell surface | - |
Treponema denticola | 9986 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.2.1.18 | 59800 | - |
x * 59800, calculated from amino acid sequence | Treponema denticola |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.2.1.18 | Treponema denticola | Q73QH2 | - |
- |
3.2.1.18 | Treponema denticola ATCC 35405 | Q73QH2 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.2.1.18 | Ni-NTA agarose column chromatography | Treponema denticola |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.2.1.18 | 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O | - |
Treponema denticola | 4-methylumbelliferone + N-acetylneuraminic acid | - |
? | |
3.2.1.18 | 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O | - |
Treponema denticola ATCC 35405 | 4-methylumbelliferone + N-acetylneuraminic acid | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.2.1.18 | ? | x * 59800, calculated from amino acid sequence | Treponema denticola |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.2.1.18 | neuraminidase | - |
Treponema denticola |
3.2.1.18 | TDE0471 | - |
Treponema denticola |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.2.1.18 | 5 | - |
- |
Treponema denticola |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.2.1.18 | physiological function | the enzyme contributes to the virulence of Treponema denticola. The enzyme protects Treponema denticola from serum killing by preventing the deposition of membrane attack complexes on the bacterial cell surface | Treponema denticola |