Literature summary extracted from

Avalos, J.L.; Bever, K.M.; Wolberger, C.
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme (2005), Mol. Cell, 17, 855-868.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.3.1.B41	expression in Escherichia coli	Archaeoglobus fulgidus

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
2.3.1.B41	crystals are grown by hanging drop method, structures of the enzyme bound to nictotinamide are determined from a single crystal diffracting to 2.4 A resolution. The structures show that free nicotinamide binds in a conserved pocket that participates in NAD+ binding and catalysis	Archaeoglobus fulgidus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.B41	Archaeoglobus fulgidus	O30124	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
2.3.1.B41	-	Archaeoglobus fulgidus

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.1.B41	Sir2Af2	-	Archaeoglobus fulgidus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)