EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.48 | Zn2+ | low nanomolar Zn2+ concentrations inhibit isoform PTB1Bll | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.3.48 | 0.0039 | - |
6,8-difluoro-4-methylumbelliferyl phosphate | at pH 7.4 and 25°C | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.48 | [a protein]-tyrosine phosphate + H2O | Homo sapiens | - |
[a protein]-tyrosine + phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.48 | Homo sapiens | P18031 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.48 | 6,8-difluoro-4-methylumbelliferyl phosphate + H2O | - |
Homo sapiens | 6,8-difluoro-4-methylumbelliferone + phosphate | - |
? | |
3.1.3.48 | [a protein]-tyrosine phosphate + H2O | - |
Homo sapiens | [a protein]-tyrosine + phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.48 | protein tyrosine phosphatase 1B | - |
Homo sapiens |
3.1.3.48 | protein tyrosine phosphatase, non-receptor type 1 | - |
Homo sapiens |
3.1.3.48 | PTP1B | - |
Homo sapiens |
3.1.3.48 | PTPN1 | - |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.3.48 | 8.66 | - |
6,8-difluoro-4-methylumbelliferyl phosphate | at pH 7.4 and 25°C | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.3.48 | 0.0000056 | - |
Zn2+ | at pH 7.4 and 25°C | Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.3.48 | physiological function | isoform PTP1B (PTPN1) regulates the insulin and leptin signalling pathway and is implicated in cancer and obesity/diabetes | Homo sapiens |