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Literature summary extracted from

  • Zheng, M.; Xu, D.
    Catalytic mechanism of hyaluronate lyase from Spectrococcus pneumonia: quantum mechanical/molecular mechanical and density functional theory studies (2013), J. Phys. Chem. B, 117, 10161-10172.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.2.1 extracellular
-
 Streptococcus pneumoniae
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.2.1 Ca2+ required Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
4.2.2.1 Streptococcus pneumoniae
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.2.2.1 [hyaluronate]n = (4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1 + 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + hyaluronate binding of the substrate molecule can lead to the ionization of Y408 and protonation of H399, Y408 serves as the general base in the proton abstraction, while general acid is the next proton donation step. The reaction can be classified into syn elimination reaction mechanism, reaction mechanism analysis, detailed overview Streptococcus pneumoniae
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.2.1 hyaluronic acid nonhydrolytic cleavage of the glycosidic bond, initiation of degradation activity analysis by molecular mechanical molecular dynamic simulations and free energy profiles, simulation and analysis of the enzyme-substrate complex structure, overview Streptococcus pneumoniae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.2.1 spnHL
-
 Streptococcus pneumoniae

General Information

EC Number General Information Comment Organism
4.2.2.1 evolution the enzyme belongs to PL subfamily 8, which has an overall alpha/alpha + beta architecture Streptococcus pneumoniae
4.2.2.1 additional information complete catalytic cycle for the degradation of hyaluronan tetrasaccharide catalyzed by the hyaluronate lyase from Spectrococcus pneumonia, overview. Active site residue is tyrosine 408. Quantum mechanical/molecular mechanical and desity calculation and modeling using truncated active site models Streptococcus pneumoniae
4.2.2.1 physiological function major function of the enzyme is to degrade hyaluronic acid Streptococcus pneumoniae