EC Number | Cloned (Comment) | Organism |
---|---|---|
4.2.1.1 | using the baculovirus expression system as a His-tagged fusion protein | Leishmania chagasi |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.1 | (2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | - |
Leishmania chagasi | |
4.2.1.1 | (2Z)-2-(3-bromobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | - |
Leishmania chagasi | |
4.2.1.1 | (2Z)-2-(3-methoxybenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | - |
Leishmania chagasi | |
4.2.1.1 | (2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | - |
Leishmania chagasi | |
4.2.1.1 | (2Z)-2-(4-fluorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | - |
Leishmania chagasi | |
4.2.1.1 | (2Z)-2-(4-methylpentan-2-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | - |
Leishmania chagasi | |
4.2.1.1 | (2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | - |
Leishmania chagasi | |
4.2.1.1 | (2Z)-2-benzylidene-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | - |
Leishmania chagasi | |
4.2.1.1 | (4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | - |
Leishmania chagasi | |
4.2.1.1 | (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | - |
Leishmania chagasi | |
4.2.1.1 | 1,2-benzothiazol-3(2H)-one 1,1-dioxide | - |
Leishmania chagasi | |
4.2.1.1 | 1-(1,2-benzoxazol-3-yl)methanesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 2-(hydroxymethyl)-4-nitro-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide | - |
Leishmania chagasi | |
4.2.1.1 | 3,5-dichloro-2-hydroxybenzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 3-aminobenzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4,5-dichlorobenzene-1,3-disulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-(2-aminoethyl)benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-(2-hydroxyethyl)benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-(aminomethyl)benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-(hydroxymethyl)benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-amino-3-bromobenzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-amino-3-chlorobenzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-amino-3-fluorobenzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-amino-6-chlorobenzene-1,3-disulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-Aminobenzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-hydroxybenzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-sulfamoylbenzoic acid | - |
Leishmania chagasi | |
4.2.1.1 | 4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 5-amino-1,3,4-thiadiazole-2-sulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide | - |
Leishmania chagasi | |
4.2.1.1 | 6-ethoxy-1,3-benzothiazole-2-sulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | acetazolamide | - |
Leishmania chagasi | |
4.2.1.1 | benzene-1,3-disulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | benzenesulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide | - |
Leishmania chagasi | |
4.2.1.1 | N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | - |
Leishmania chagasi | |
4.2.1.1 | N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | - |
Leishmania chagasi | |
4.2.1.1 | N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | - |
Leishmania chagasi | |
4.2.1.1 | [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate | - |
Leishmania chagasi |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.1 | 0.0158 | - |
CO2 | pH 7.5, 20°C | Leishmania chagasi |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
4.2.1.1 | 35000 | - |
SDS-PAGE | Leishmania chagasi |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.1 | Leishmania chagasi | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.1 | CO2 + H2O | - |
Leishmania chagasi | H2CO3 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.2.1.1 | beta-carbonic anhydrase | - |
Leishmania chagasi |
4.2.1.1 | LdcCA | - |
Leishmania chagasi |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.1 | 935000 | - |
CO2 | pH 7.5, 20°C | Leishmania chagasi |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.1 | 0.0000134 | - |
(2Z)-2-(3-bromobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000184 | - |
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000195 | - |
(2Z)-2-(4-methylpentan-2-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000279 | - |
(2Z)-2-benzylidene-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000331 | - |
(2Z)-2-(4-fluorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000401 | - |
(2Z)-2-(3-methoxybenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000502 | - |
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000502 | - |
2-(hydroxymethyl)-4-nitro-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000515 | - |
6-ethoxy-1,3-benzothiazole-2-sulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000596 | - |
4-sulfamoylbenzoic acid | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000734 | - |
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000074 | - |
N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000871 | - |
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000871 | - |
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000917 | - |
acetazolamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000917 | - |
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000951 | - |
5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0000953 | - |
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000136 | - |
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000144 | - |
(2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000152 | - |
(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000189 | - |
4,5-dichlorobenzene-1,3-disulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000227 | - |
4-(2-hydroxyethyl)benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000236 | - |
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000316 | - |
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000338 | - |
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000389 | - |
4-(hydroxymethyl)benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000433 | - |
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000584 | - |
5-amino-1,3,4-thiadiazole-2-sulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000705 | - |
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000764 | - |
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000806 | - |
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000834 | - |
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.000927 | - |
4-hydroxybenzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.004819 | - |
4-amino-6-chlorobenzene-1,3-disulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.00596 | - |
3-aminobenzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.00842 | - |
4-amino-3-bromobenzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.00891 | - |
benzene-1,3-disulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.009058 | - |
4-amino-3-chlorobenzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.009083 | - |
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.009135 | - |
3,5-dichloro-2-hydroxybenzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.009251 | - |
4-Aminobenzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.0156 | - |
4-amino-3-fluorobenzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.1 | - |
4-(aminomethyl)benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.1 | - |
4-(2-aminoethyl)benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.1 | - |
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.1 | - |
benzenesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.1 | - |
1-(1,2-benzoxazol-3-yl)methanesulfonamide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.1 | - |
1,2-benzothiazol-3(2H)-one 1,1-dioxide | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.1 | - |
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate | pH 7.5, 20°C | Leishmania chagasi | |
4.2.1.1 | 0.1 | - |
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide | pH 7.5, 20°C | Leishmania chagasi |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.1 | 59000 | - |
CO2 | pH 7.5, 20°C | Leishmania chagasi |