BRENDA - Enzyme Database show

Cloning, characterization, and sulfonamide and thiol inhibition studies of an alpha-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease

Pan, P.; Vermelho, A.B.; Capaci Rodrigues, G.; Scozzafava, A.; Tolvanen, M.E.; Parkkila, S.; Capasso, C.; Supuran, C.T.; J. Med. Chem. 56, 1761-1771 (2013)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
4.2.1.1
in Escherichia coli as a GST-fusion protein
Malassezia globosa
4.2.1.1
using the baculovirus expression system as a His-tagged fusion protein
Trypanosoma cruzi
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.1
(2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-(3-bromobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-(3-methoxybenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-(4-methylpentan-2-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-benzylidene-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
-
Malassezia globosa
4.2.1.1
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
-
Trypanosoma cruzi
4.2.1.1
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
Malassezia globosa
4.2.1.1
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
Trypanosoma cruzi
4.2.1.1
1,2-benzothiazol-3(2H)-one 1,1-dioxide
-
Trypanosoma cruzi
4.2.1.1
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
Malassezia globosa
4.2.1.1
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
Trypanosoma cruzi
4.2.1.1
2-(hydroxymethyl)-4-nitro-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
2-aminobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
-
Malassezia globosa
4.2.1.1
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
-
Trypanosoma cruzi
4.2.1.1
3,5-dichloro-2-hydroxybenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
3-(4-sulfamoylphenyl)propanoic acid
-
Malassezia globosa
4.2.1.1
3-aminobenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4,5-dichlorobenzene-1,3-disulfonamide
-
Malassezia globosa
4.2.1.1
4,5-dichlorobenzene-1,3-disulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(2-aminoethyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-(2-aminoethyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(2-hydroxyethyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-(2-hydroxyethyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(aminomethyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-(aminomethyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(hydroxymethyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-(hydroxymethyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-3,bromobenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-3-bromobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-3-chlorobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-3-chlorobenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-3-fluorobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-3-fluorobenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-3-iodobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-Aminobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-Aminobenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-bromobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-bromophenyl sulfamate
-
Malassezia globosa
4.2.1.1
4-hydroxybenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-sulfamoylbenzoic acid
-
Malassezia globosa
4.2.1.1
4-sulfamoylbenzoic acid
-
Trypanosoma cruzi
4.2.1.1
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
5-(3-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
Malassezia globosa
4.2.1.1
5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide
-
Trypanosoma cruzi
4.2.1.1
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Malassezia globosa
4.2.1.1
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Trypanosoma cruzi
4.2.1.1
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Malassezia globosa
4.2.1.1
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Trypanosoma cruzi
4.2.1.1
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
Malassezia globosa
4.2.1.1
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
Trypanosoma cruzi
4.2.1.1
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
-
Trypanosoma cruzi
4.2.1.1
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
Malassezia globosa
4.2.1.1
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
Trypanosoma cruzi
4.2.1.1
acetazolamide
-
Trypanosoma cruzi
4.2.1.1
benzene-1,3-disulfonamide
-
Trypanosoma cruzi
4.2.1.1
benzenesulfonamide
-
Malassezia globosa
4.2.1.1
benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
-
Malassezia globosa
4.2.1.1
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
-
Trypanosoma cruzi
4.2.1.1
N-(4-bromophenyl)sulfuric diamide
-
Malassezia globosa
4.2.1.1
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
-
Malassezia globosa
4.2.1.1
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
-
Trypanosoma cruzi
4.2.1.1
N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
N-phenylsulfuric diamide
-
Malassezia globosa
4.2.1.1
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
-
Malassezia globosa
4.2.1.1
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
-
Trypanosoma cruzi
4.2.1.1
phenyl sulfamate
-
Malassezia globosa
4.2.1.1
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
-
Malassezia globosa
4.2.1.1
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
-
Trypanosoma cruzi
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
4.2.1.1
8.1
-
CO2
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
8.1
-
CO2
pH 7.5, 20°C
Trypanosoma cruzi
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.2.1.1
34000
-
SDS-PAGE
Malassezia globosa
4.2.1.1
34000
-
SDS-PAGE
Trypanosoma cruzi
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.1
Malassezia globosa
-
-
-
4.2.1.1
Trypanosoma cruzi
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.1
CO2 + H2O
-
730163
Trypanosoma cruzi
H2CO3
-
-
-
?
4.2.1.1
CO2 + H2O
-
730163
Malassezia globosa
H2CO3
-
-
-
?
Turnover Number [1/s]
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
4.2.1.1
860000
-
CO2
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
1210000
-
CO2
pH 7.5, 20°C
Trypanosoma cruzi
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
4.2.1.1
0.0000211
-
(2Z)-2-benzylidene-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000345
-
(2Z)-2-(3-methoxybenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000431
-
(2Z)-2-(3-bromobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000524
-
(2Z)-2-(4-methylpentan-2-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000616
-
acetazolamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000616
-
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000063
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000643
-
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000068
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000719
-
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000725
-
(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000749
-
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000079
-
(2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000079
-
4-(2-aminoethyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000827
-
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000845
-
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000855
-
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000873
-
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000879
-
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000882
-
6-ethoxy-1,3-benzothiazole-2-sulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000885
-
5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00009
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000911
-
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000092
-
4-amino-6-chlorobenzene-1,3-disulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000929
-
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000936
-
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000094
-
4-sulfamoylbenzoic acid
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000947
-
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000104
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000113
-
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000116
-
4-amino-3-fluorobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000118
-
4-(2-hydroxyethyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000121
-
4-amino-3-chlorobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000125
-
N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000128
-
4,5-dichlorobenzene-1,3-disulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000134
-
2-(hydroxymethyl)-4-nitro-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000134
-
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000152
-
3-(4-sulfamoylphenyl)propanoic acid
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000174
-
4-(aminomethyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000192
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000234
-
4-(hydroxymethyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000236
-
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000243
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000245
-
4-Aminobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00032
-
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000346
-
4,5-dichlorobenzene-1,3-disulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000349
-
4-amino-3-bromobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000365
-
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000374
-
4-bromophenyl sulfamate
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000413
-
N-(4-bromophenyl)sulfuric diamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000482
-
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000534
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000543
-
4-amino-3-iodobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00065
-
4-bromobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000652
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00081
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00082
-
4-amino-6-chlorobenzene-1,3-disulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000842
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000867
-
1-(1,2-benzoxazol-3-yl)methanesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00146
-
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00256
-
phenyl sulfamate
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0031
-
N-phenylsulfuric diamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00453
-
benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00674
-
benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.006925
-
4-amino-3-chlorobenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.007231
-
4-(aminomethyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00765
-
1-(1,2-benzoxazol-3-yl)methanesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00813
-
4-amino-3-fluorobenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00821
-
1,2-benzothiazol-3(2H)-one 1,1-dioxide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00852
-
4-amino-3,bromobenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.009238
-
4-(2-aminoethyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.009433
-
3,5-dichloro-2-hydroxybenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0098
-
2-aminobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.02546
-
3-aminobenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0315
-
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0348
-
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.035
-
5-(3-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.038
-
6-ethoxy-1,3-benzothiazole-2-sulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0442
-
benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0573
-
4-Aminobenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0638
-
benzene-1,3-disulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.06675
-
4-(2-hydroxyethyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.07185
-
4-(hydroxymethyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.07388
-
4-hydroxybenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.07455
-
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.076
-
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.079
-
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.079
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.084
-
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.084
-
4-sulfamoylbenzoic acid
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.085
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
pH 8.3, 20°C
Malassezia globosa
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
4.2.1.1
in Escherichia coli as a GST-fusion protein
Malassezia globosa
4.2.1.1
using the baculovirus expression system as a His-tagged fusion protein
Trypanosoma cruzi
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.1
(2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-(3-bromobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-(3-methoxybenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-(4-methylpentan-2-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(2Z)-2-benzylidene-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
-
Malassezia globosa
4.2.1.1
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
-
Trypanosoma cruzi
4.2.1.1
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
Malassezia globosa
4.2.1.1
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
Trypanosoma cruzi
4.2.1.1
1,2-benzothiazol-3(2H)-one 1,1-dioxide
-
Trypanosoma cruzi
4.2.1.1
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
Malassezia globosa
4.2.1.1
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
Trypanosoma cruzi
4.2.1.1
2-(hydroxymethyl)-4-nitro-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
2-aminobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
-
Malassezia globosa
4.2.1.1
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
-
Trypanosoma cruzi
4.2.1.1
3,5-dichloro-2-hydroxybenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
3-(4-sulfamoylphenyl)propanoic acid
-
Malassezia globosa
4.2.1.1
3-aminobenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4,5-dichlorobenzene-1,3-disulfonamide
-
Malassezia globosa
4.2.1.1
4,5-dichlorobenzene-1,3-disulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(2-aminoethyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-(2-aminoethyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(2-hydroxyethyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-(2-hydroxyethyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(aminomethyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-(aminomethyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-(hydroxymethyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-(hydroxymethyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-3,bromobenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-3-bromobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-3-chlorobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-3-chlorobenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-3-fluorobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-3-fluorobenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-3-iodobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-Aminobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-Aminobenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-bromobenzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-bromophenyl sulfamate
-
Malassezia globosa
4.2.1.1
4-hydroxybenzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-sulfamoylbenzoic acid
-
Malassezia globosa
4.2.1.1
4-sulfamoylbenzoic acid
-
Trypanosoma cruzi
4.2.1.1
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
-
Malassezia globosa
4.2.1.1
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
5-(3-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
Malassezia globosa
4.2.1.1
5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide
-
Trypanosoma cruzi
4.2.1.1
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Malassezia globosa
4.2.1.1
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Trypanosoma cruzi
4.2.1.1
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Malassezia globosa
4.2.1.1
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Trypanosoma cruzi
4.2.1.1
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
Malassezia globosa
4.2.1.1
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
Trypanosoma cruzi
4.2.1.1
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
-
Trypanosoma cruzi
4.2.1.1
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
Malassezia globosa
4.2.1.1
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
Trypanosoma cruzi
4.2.1.1
acetazolamide
-
Trypanosoma cruzi
4.2.1.1
benzene-1,3-disulfonamide
-
Trypanosoma cruzi
4.2.1.1
benzenesulfonamide
-
Malassezia globosa
4.2.1.1
benzenesulfonamide
-
Trypanosoma cruzi
4.2.1.1
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
-
Malassezia globosa
4.2.1.1
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
-
Trypanosoma cruzi
4.2.1.1
N-(4-bromophenyl)sulfuric diamide
-
Malassezia globosa
4.2.1.1
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
-
Malassezia globosa
4.2.1.1
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
-
Trypanosoma cruzi
4.2.1.1
N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
-
Trypanosoma cruzi
4.2.1.1
N-phenylsulfuric diamide
-
Malassezia globosa
4.2.1.1
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
-
Malassezia globosa
4.2.1.1
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
-
Trypanosoma cruzi
4.2.1.1
phenyl sulfamate
-
Malassezia globosa
4.2.1.1
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
-
Malassezia globosa
4.2.1.1
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
-
Trypanosoma cruzi
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
4.2.1.1
0.0000211
-
(2Z)-2-benzylidene-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000345
-
(2Z)-2-(3-methoxybenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000431
-
(2Z)-2-(3-bromobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000524
-
(2Z)-2-(4-methylpentan-2-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000616
-
acetazolamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000616
-
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000063
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000643
-
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000068
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000719
-
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000725
-
(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000749
-
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000079
-
(2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000079
-
4-(2-aminoethyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000827
-
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000845
-
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000855
-
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000873
-
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000879
-
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000882
-
6-ethoxy-1,3-benzothiazole-2-sulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000885
-
5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00009
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000911
-
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000092
-
4-amino-6-chlorobenzene-1,3-disulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000929
-
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0000936
-
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000094
-
4-sulfamoylbenzoic acid
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0000947
-
(2Z)-2-(4-chlorobenzylidene)-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000104
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000113
-
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000116
-
4-amino-3-fluorobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000118
-
4-(2-hydroxyethyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000121
-
4-amino-3-chlorobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000125
-
N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000128
-
4,5-dichlorobenzene-1,3-disulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000134
-
2-(hydroxymethyl)-4-nitro-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000134
-
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000152
-
3-(4-sulfamoylphenyl)propanoic acid
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000174
-
4-(aminomethyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000192
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000234
-
4-(hydroxymethyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000236
-
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000243
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000245
-
4-Aminobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00032
-
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000346
-
4,5-dichlorobenzene-1,3-disulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000349
-
4-amino-3-bromobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000365
-
4-amino-N-(4-sulfamoylphenyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000374
-
4-bromophenyl sulfamate
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000413
-
N-(4-bromophenyl)sulfuric diamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000482
-
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000534
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000543
-
4-amino-3-iodobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00065
-
4-bromobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.000652
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00081
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00082
-
4-amino-6-chlorobenzene-1,3-disulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000842
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.000867
-
1-(1,2-benzoxazol-3-yl)methanesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00146
-
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00256
-
phenyl sulfamate
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0031
-
N-phenylsulfuric diamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00453
-
benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00674
-
benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.006925
-
4-amino-3-chlorobenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.007231
-
4-(aminomethyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00765
-
1-(1,2-benzoxazol-3-yl)methanesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.00813
-
4-amino-3-fluorobenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00821
-
1,2-benzothiazol-3(2H)-one 1,1-dioxide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.00852
-
4-amino-3,bromobenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.009238
-
4-(2-aminoethyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.009433
-
3,5-dichloro-2-hydroxybenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0098
-
2-aminobenzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.02546
-
3-aminobenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0315
-
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0348
-
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.035
-
5-(3-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.038
-
6-ethoxy-1,3-benzothiazole-2-sulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.0442
-
benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0573
-
4-Aminobenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.0638
-
benzene-1,3-disulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.06675
-
4-(2-hydroxyethyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.07185
-
4-(hydroxymethyl)benzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.07388
-
4-hydroxybenzenesulfonamide
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.07455
-
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.076
-
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.079
-
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.079
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.084
-
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
0.084
-
4-sulfamoylbenzoic acid
pH 7.5, 20°C
Trypanosoma cruzi
4.2.1.1
0.085
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
pH 8.3, 20°C
Malassezia globosa
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
4.2.1.1
8.1
-
CO2
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
8.1
-
CO2
pH 7.5, 20°C
Trypanosoma cruzi
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.2.1.1
34000
-
SDS-PAGE
Malassezia globosa
4.2.1.1
34000
-
SDS-PAGE
Trypanosoma cruzi
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.1
CO2 + H2O
-
730163
Trypanosoma cruzi
H2CO3
-
-
-
?
4.2.1.1
CO2 + H2O
-
730163
Malassezia globosa
H2CO3
-
-
-
?
Turnover Number [1/s] (protein specific)
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
4.2.1.1
860000
-
CO2
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
1210000
-
CO2
pH 7.5, 20°C
Trypanosoma cruzi
KCat/KM [mM/s]
EC Number
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
4.2.1.1
69000
-
CO2
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
149000
-
CO2
pH 7.5, 20°C
Trypanosoma cruzi
KCat/KM [mM/s] (protein specific)
EC Number
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
4.2.1.1
69000
-
CO2
pH 8.3, 20°C
Malassezia globosa
4.2.1.1
149000
-
CO2
pH 7.5, 20°C
Trypanosoma cruzi