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Literature summary extracted from
- The tryptophan synthase alpha2beta2 complex: a model for substrate channeling, allosteric communication, and pyridoxal phosphate catalysis (2013), J. Biol. Chem., 288, 10084-10091.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.20 | 2,3-dihydro-L-tryptophan | very good competitive inhibitor | Salmonella enterica subsp. enterica serovar Typhimurium |  |
| 4.2.1.20 | oxindolyl-L-alanine | very good competitive inhibitor | Salmonella enterica subsp. enterica serovar Typhimurium | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.20 | L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | overall reaction | L-tryptophan + D-glyceraldehyde 3-phosphate + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.20 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.20 | (3S)-2,3-dihydro-5-fluoro-L-tryptophan | isomerization | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| 4.2.1.20 | 5-fluoro-L-tryptophan | isomerization | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| 4.2.1.20 | indole-3-glycerol phosphate | reaction catalyzed by the alpha subunit | Salmonella enterica subsp. enterica serovar Typhimurium | indole + D-glyceraldehyde 3-phosphate | - |
r | |
| 4.2.1.20 | L-Ser + indole | reaction catalyzed by the beta subunit | Salmonella enterica subsp. enterica serovar Typhimurium | L-tryptophan + H2O | - |
ir | |
| 4.2.1.20 | L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate | overall reaction | Salmonella enterica subsp. enterica serovar Typhimurium | L-tryptophan + D-glyceraldehyde 3-phosphate + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.1.20 | heterotetramer | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
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Release 2023.1 (January 2023)
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