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Literature summary extracted from

  • Eichmann, T.O.; Kumari, M.; Haas, J.T.; Farese, R.V.; Zimmermann, R.; Lass, A.; Zechner, R.
    Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases (2012), J. Biol. Chem., 287, 41446-41457.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.3 CGI-58 co-activator Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.3 expressed in in Cos-7 cells Mus musculus
3.1.1.79 recombinant expression of His-tagged enzyme Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.79 76-0079 a commercial small molecule inhibitor Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.79 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.3 additional information Mus musculus the enzyme hydrolyzes long-chain fatty acid esters in vivo with a modest substrate preference for C16:1 ?
-
 ?
3.1.1.3 additional information Mus musculus C57BL/6 the enzyme hydrolyzes long-chain fatty acid esters in vivo with a modest substrate preference for C16:1 ?
-
 ?
3.1.1.3 triacylglycerol + H2O Mus musculus
-
 diacylglycerol + a carboxylate the enzyme specifically generates sn-1,3 and, in the presence of its co-activator CGI-58, sn-1,3 and sn-2,3 diacylglycerol ?
3.1.1.3 triacylglycerol + H2O Mus musculus C57BL/6
-
 diacylglycerol + a carboxylate the enzyme specifically generates sn-1,3 and, in the presence of its co-activator CGI-58, sn-1,3 and sn-2,3 diacylglycerol ?
3.1.1.79 diacylglycerol + H2O Mus musculus
-
 monoacylglycerol + a carboxylate
-
 ?
3.1.1.79 additional information Mus musculus sn-1,3-diacylglycerol is the preferred substrate for the consecutive hydrolysis by hormone-sensitive lipase, the enzyme is less active with sn-1,2-diacylglycerol ?
-
 ?
3.1.1.79 triacylglycerol + H2O Mus musculus
-
 diacylglycerol + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.3 Mus musculus
-
-
-
3.1.1.79 Mus musculus
-
-
-
3.1.1.79 Mus musculus C57BL/6
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.79 white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.3 additional information the enzyme hydrolyzes long-chain fatty acid esters in vivo with a modest substrate preference for C16:1 Mus musculus ?
-
 ?
3.1.1.3 additional information the enzyme hydrolyzes long-chain fatty acid esters in vivo with a modest substrate preference for C16:1 Mus musculus C57BL/6 ?
-
 ?
3.1.1.3 triacylglycerol + H2O
-
 Mus musculus diacylglycerol + a carboxylate the enzyme specifically generates sn-1,3 and, in the presence of its co-activator CGI-58, sn-1,3 and sn-2,3 diacylglycerol ?
3.1.1.3 triacylglycerol + H2O
-
 Mus musculus C57BL/6 diacylglycerol + a carboxylate the enzyme specifically generates sn-1,3 and, in the presence of its co-activator CGI-58, sn-1,3 and sn-2,3 diacylglycerol ?
3.1.1.3 trilinolein + H2O lowest activity Mus musculus ?
-
 ?
3.1.1.3 trilinolein + H2O lowest activity Mus musculus C57BL/6 ?
-
 ?
3.1.1.3 trilinolenin + H2O
-
 Mus musculus ?
-
 ?
3.1.1.3 trilinolenin + H2O
-
 Mus musculus C57BL/6 ?
-
 ?
3.1.1.3 triolein + H2O
-
 Mus musculus ?
-
 ?
3.1.1.3 triolein + H2O
-
 Mus musculus C57BL/6 ?
-
 ?
3.1.1.3 tripalmitolein + H2O highest activity Mus musculus ?
-
 ?
3.1.1.79 diacylglycerol + H2O
-
 Mus musculus monoacylglycerol + a carboxylate
-
 ?
3.1.1.79 additional information sn-1,3-diacylglycerol is the preferred substrate for the consecutive hydrolysis by hormone-sensitive lipase, the enzyme is less active with sn-1,2-diacylglycerol Mus musculus ?
-
 ?
3.1.1.79 triacylglycerol + H2O
-
 Mus musculus diacylglycerol + a carboxylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.3 adipose triglyceride lipase
-
 Mus musculus
3.1.1.3 ATGL
-
 Mus musculus
3.1.1.79 HSL
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.1.79 malfunction enzyme-deficient mice accumulate sn-1,3-diacylglycerol and sn-2,3-diacylglycerol in white adipose tissue Mus musculus
3.1.1.79 physiological function the enzyme is crucial for the hydrolysis of diacylglycerol within the lipolytic cascade Mus musculus