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Literature summary extracted from

  • Xu, J.; Kurup, P.; Bartos, J.A.; Patriarchi, T.; Hell, J.W.; Lombroso, P.J.
    Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity (2012), J. Biol. Chem., 287, 20942-20956.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.48 expressed in Escherichia coli BL21(DE3) cells Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.48 [a protein]-tyrosine phosphate + H2O Mus musculus
-
 [a protein]-tyrosine + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.48 glutathione-Sepharose or Talon metal affinity resin bead chromatography Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 brain
-
 Mus musculus
-
3.1.3.48 striatum
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 phosphorylated proline-rich tyrosine kinase 2 + H2O the enzyme directly binds to and dephosphorylates proline-rich tyrosine kinase 2 at Tyr402 Mus musculus proline-rich tyrosine kinase 2 + phosphate
-
 ?
3.1.3.48 [a protein]-tyrosine phosphate + H2O
-
 Mus musculus [a protein]-tyrosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 STEP
-
 Mus musculus
3.1.3.48 striatal-enriched protein-tyrosine phosphatase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.3.48 metabolism striatal-enriched protein-tyrosine phosphatase regulates proline-rich tyrosine kinase 2 activity Mus musculus