Literature summary extracted from
Decker, H.; Motamedi, H.; Hutchinson, C.R.
Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens (1993), J. Bacteriol., 175, 3876-3886.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
1.14.13.200 |
expression in Streptomyces lividans |
Streptomyces glaucescens |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.14.13.200 |
Streptomyces glaucescens |
P39888 |
- |
- |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
1.14.13.200 |
tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ |
- |
Streptomyces glaucescens |
tetracenomycin C + 2 NAD(P)+ + H2O |
enzyme is responsible for the hydroxylation of tetracenomycin A2 at positions C-4, C-4a, and C-12a to give tetracenomycin C |
? |
|
Temperature Optimum [°C]
EC Number |
Temperature Optimum [°C] |
Temperature Optimum Maximum [°C] |
Comment |
Organism |
---|
1.14.13.200 |
30 |
- |
assay at |
Streptomyces glaucescens |
pH Optimum
EC Number |
pH Optimum Minimum |
pH Optimum Maximum |
Comment |
Organism |
---|
1.14.13.200 |
7.5 |
- |
assay at |
Streptomyces glaucescens |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
1.14.13.200 |
physiological function |
enzyme is responsible for the hydroxylation of tetracenomycin A2 at positions C-4, C-4a, and C-12a to give tetracenomycin C, i.e. the final step in tetracenomycin C biosynthesis |
Streptomyces glaucescens |