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Literature summary extracted from

  • Decker, H.; Motamedi, H.; Hutchinson, C.R.
    Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens (1993), J. Bacteriol., 175, 3876-3886.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.13.200 expression in Streptomyces lividans Streptomyces glaucescens

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.200 Streptomyces glaucescens P39888
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.200 tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+
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Streptomyces glaucescens tetracenomycin C + 2 NAD(P)+ + H2O enzyme is responsible for the hydroxylation of tetracenomycin A2 at positions C-4, C-4a, and C-12a to give tetracenomycin C ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.13.200 30
-
assay at Streptomyces glaucescens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.200 7.5
-
assay at Streptomyces glaucescens

General Information

EC Number General Information Comment Organism
1.14.13.200 physiological function enzyme is responsible for the hydroxylation of tetracenomycin A2 at positions C-4, C-4a, and C-12a to give tetracenomycin C, i.e. the final step in tetracenomycin C biosynthesis Streptomyces glaucescens