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Literature summary extracted from

  • Smirnov, D.; Dhall, A.; Sivanesam, K.; Sharar, R.J.; Chatterjee, C.
    Fluorescent probes reveal a minimal ligase recognition motif in the prokaryotic ubiquitin-like protein from Mycobacterium tuberculosis (2013), J. Am. Chem. Soc., 135, 2887-2890.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
6.3.1.19 Mycobacterium tuberculosis P9WNU7
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-
6.3.1.19 Mycobacterium tuberculosis ATCC 25618 P9WNU7
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.1.19 ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine the C-terminal 26 amino acid sequence of the prokaryotic ubiquitin-like protein (Pup) is the minimal ligase recognition motif in Mycobacterium tuberculosis. Specific hydrophobic residues within this sequence that are known to be important for the interactions of Pup with proteasomes are also critical for the activation of Pup by PafA Mycobacterium tuberculosis ADP + phosphate + N6-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine
-
 ?
6.3.1.19 ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine the C-terminal 26 amino acid sequence of the prokaryotic ubiquitin-like protein (Pup) is the minimal ligase recognition motif in Mycobacterium tuberculosis. Specific hydrophobic residues within this sequence that are known to be important for the interactions of Pup with proteasomes are also critical for the activation of Pup by PafA Mycobacterium tuberculosis ATCC 25618 ADP + phosphate + N6-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.1.19 PafA ambiguous Mycobacterium tuberculosis
6.3.1.19 Pup ligase
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 Mycobacterium tuberculosis