BRENDA - Enzyme Database show

Thiosuccinyl peptides as Sirt5-specific inhibitors

He, B.; Du, J.; Lin, H.; J. Am. Chem. Soc. 134, 1922-1925 (2012)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.B43
(N6-thiosuccinyl)KSTGGKA
-
Homo sapiens
2.3.1.B43
Ac-AR(N6-thiosuccinyl)KST-NH2
-
Homo sapiens
2.3.1.B43
Ac-RR(N6-thiosuccinyl)KRR-NH2
-
Homo sapiens
2.3.1.B43
AGK2
40% inhibition at 0.1 mM
Homo sapiens
2.3.1.B43
AR(N6-thiosuccinyl)KST
-
Homo sapiens
2.3.1.B43
KQTAR(N6-thiosuccinyl)K
-
Homo sapiens
2.3.1.B43
KQTAR(N6-thiosuccinyl)KSTGGKA
-
Homo sapiens
2.3.1.B43
additional information
H3K9TAc and sirtinol show no inhibnition at 0.1 mM
Homo sapiens
2.3.1.B43
nicotinamide
-
Homo sapiens
2.3.1.B43
suramin
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.B43
Homo sapiens
Q9NXA8
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.B43
NAD+ + KQTAR(N6-succinyl)KSTGGKA
-
729885
Homo sapiens
nicotinamide + KQTARKSTGGKA + 2'-O-succinyl-ADP-ribose
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.3.1.B43
0.001
-
pH and temperature not specified in the publication
Homo sapiens
KQTAR(N6-thiosuccinyl)K
2.3.1.B43
0.001
-
pH and temperature not specified in the publication
Homo sapiens
(N6-thiosuccinyl)KSTGGKA
2.3.1.B43
0.005
-
pH and temperature not specified in the publication
Homo sapiens
KQTAR(N6-thiosuccinyl)KSTGGKA
2.3.1.B43
0.025
-
pH and temperature not specified in the publication
Homo sapiens
Ac-RR(N6-thiosuccinyl)KRR-NH2
2.3.1.B43
0.025
-
pH and temperature not specified in the publication
Homo sapiens
suramin
2.3.1.B43
0.03
-
pH and temperature not specified in the publication
Homo sapiens
AR(N6-thiosuccinyl)KST
2.3.1.B43
0.04
-
pH and temperature not specified in the publication
Homo sapiens
Ac-AR(N6-thiosuccinyl)KST-NH2
2.3.1.B43
0.15
-
pH and temperature not specified in the publication
Homo sapiens
nicotinamide
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.3.1.B43
0.001
-
pH and temperature not specified in the publication
Homo sapiens
KQTAR(N6-thiosuccinyl)K
2.3.1.B43
0.001
-
pH and temperature not specified in the publication
Homo sapiens
(N6-thiosuccinyl)KSTGGKA
2.3.1.B43
0.005
-
pH and temperature not specified in the publication
Homo sapiens
KQTAR(N6-thiosuccinyl)KSTGGKA
2.3.1.B43
0.025
-
pH and temperature not specified in the publication
Homo sapiens
Ac-RR(N6-thiosuccinyl)KRR-NH2
2.3.1.B43
0.025
-
pH and temperature not specified in the publication
Homo sapiens
suramin
2.3.1.B43
0.03
-
pH and temperature not specified in the publication
Homo sapiens
AR(N6-thiosuccinyl)KST
2.3.1.B43
0.04
-
pH and temperature not specified in the publication
Homo sapiens
Ac-AR(N6-thiosuccinyl)KST-NH2
2.3.1.B43
0.15
-
pH and temperature not specified in the publication
Homo sapiens
nicotinamide
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.B43
(N6-thiosuccinyl)KSTGGKA
-
Homo sapiens
2.3.1.B43
Ac-AR(N6-thiosuccinyl)KST-NH2
-
Homo sapiens
2.3.1.B43
Ac-RR(N6-thiosuccinyl)KRR-NH2
-
Homo sapiens
2.3.1.B43
AGK2
40% inhibition at 0.1 mM
Homo sapiens
2.3.1.B43
AR(N6-thiosuccinyl)KST
-
Homo sapiens
2.3.1.B43
KQTAR(N6-thiosuccinyl)K
-
Homo sapiens
2.3.1.B43
KQTAR(N6-thiosuccinyl)KSTGGKA
-
Homo sapiens
2.3.1.B43
additional information
H3K9TAc and sirtinol show no inhibnition at 0.1 mM
Homo sapiens
2.3.1.B43
nicotinamide
-
Homo sapiens
2.3.1.B43
suramin
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.B43
NAD+ + KQTAR(N6-succinyl)KSTGGKA
-
729885
Homo sapiens
nicotinamide + KQTARKSTGGKA + 2'-O-succinyl-ADP-ribose
-
-
-
?