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Literature summary extracted from

  • Sutter, M.; Damberger, F.F.; Imkamp, F.; Allain, F.H.; Weber-Ban, E.
    Prokaryotic ubiquitin-like protein (Pup) is coupled to substrates via the side chain of its C-terminal glutamate (2010), J. Am. Chem. Soc., 132, 5610-5612.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.1.19 ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine Mycobacterium tuberculosis pupylation targets the substrates for degradation by the proteasome ADP + phosphate + N6-[[prokaryotic ubiquitin-like protein]-L-glutamate]-[[protein]-L-lysine]
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 ?
6.3.1.19 ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine Mycobacterium tuberculosis ATCC 25618 pupylation targets the substrates for degradation by the proteasome ADP + phosphate + N6-[[prokaryotic ubiquitin-like protein]-L-glutamate]-[[protein]-L-lysine]
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Organism

EC Number Organism UniProt Comment Textmining
6.3.1.19 Mycobacterium tuberculosis P9WNU7
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-
6.3.1.19 Mycobacterium tuberculosis ATCC 25618 P9WNU7
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-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.1.19
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.1.19 ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein PanB]-L-lysine the C-terminal glutamate of Pup-GGE is coupled to the protein substrate PanB lysine residue via the side-chain carboxylate Mycobacterium tuberculosis ADP + phosphate + N6-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein PanB]-L-lysine
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 ?
6.3.1.19 ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein PanB]-L-lysine the C-terminal glutamate of Pup-GGE is coupled to the protein substrate PanB lysine residue via the side-chain carboxylate Mycobacterium tuberculosis ATCC 25618 ADP + phosphate + N6-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein PanB]-L-lysine
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 ?
6.3.1.19 ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine Pup is linked to substrate proteins by the formation of an isopeptide bond between the side-chain carboxylate of glutamate64 and a lysine side chain of the substrate protein Mycobacterium tuberculosis ADP + phosphate + N6-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine
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 ?
6.3.1.19 ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine Pup is linked to substrate proteins by the formation of an isopeptide bond between the side-chain carboxylate of glutamate64 and a lysine side chain of the substrate protein Mycobacterium tuberculosis ATCC 25618 ADP + phosphate + N6-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine
-
 ?
6.3.1.19 ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine pupylation targets the substrates for degradation by the proteasome Mycobacterium tuberculosis ADP + phosphate + N6-[[prokaryotic ubiquitin-like protein]-L-glutamate]-[[protein]-L-lysine]
-
 ?
6.3.1.19 ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine pupylation targets the substrates for degradation by the proteasome Mycobacterium tuberculosis ATCC 25618 ADP + phosphate + N6-[[prokaryotic ubiquitin-like protein]-L-glutamate]-[[protein]-L-lysine]
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 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.1.19 PafA ambiguous Mycobacterium tuberculosis