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Literature summary extracted from

  • Sunitha, K.; Suresh, P.; Santhosh, M.S.; Hemshekhar, M.; Thushara, R.M.; Marathe, G.K.; Thirunavukkarasu, C.; Kemparaju, K.; Kumar, M.S.; Girish, K.S.
    Inhibition of hyaluronidase by N-acetyl cysteine and glutathione: role of thiol group in hyaluronan protection (2013), Int. J. Biol. Macromol., 55, 39-46.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.35 glutathione non-competitive Apis mellifera
3.2.1.35 glutathione non-competitive Bos taurus
3.2.1.35 glutathione non-competitive Echis carinatus
3.2.1.35 glutathione non-competitive, complete inhibition at 1.8 mg/ml Homo sapiens
3.2.1.35 N-acetyl-L-cysteine non-competitive Apis mellifera
3.2.1.35 N-acetyl-L-cysteine non-competitive Bos taurus
3.2.1.35 N-acetyl-L-cysteine non-competitive Echis carinatus
3.2.1.35 N-acetyl-L-cysteine non-competitive, complete inhibition at 1.8 mg/ml Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.35 extracellular
-
 Apis mellifera
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.35 Apis mellifera Q08169
-
-
3.2.1.35 Bos taurus
-
-
-
3.2.1.35 Echis carinatus
-
-
-
3.2.1.35 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.35 serum
-
 Homo sapiens
-
3.2.1.35 testis
-
 Bos taurus
-
3.2.1.35 venom
-
 Echis carinatus
-
3.2.1.35 venom
-
 Apis mellifera
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.35 hyaluronic acid + H2O
-
 Homo sapiens ?
-
 ?
3.2.1.35 hyaluronic acid + H2O
-
 Bos taurus ?
-
 ?
3.2.1.35 hyaluronic acid + H2O
-
 Echis carinatus ?
-
 ?
3.2.1.35 hyaluronic acid + H2O
-
 Apis mellifera ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.35 HAase
-
 Homo sapiens
3.2.1.35 HAase
-
 Bos taurus
3.2.1.35 HAase
-
 Echis carinatus
3.2.1.35 HAase
-
 Apis mellifera
3.2.1.35 hyaluronidase
-
 Homo sapiens
3.2.1.35 hyaluronidase
-
 Bos taurus
3.2.1.35 hyaluronidase
-
 Echis carinatus
3.2.1.35 hyaluronidase
-
 Apis mellifera

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.35 4
-
 in 0.2 M sodium acetate buffer pH 5.5 containing 0.15 M NaCl at 37°C Bos taurus N-acetyl-L-cysteine