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Literature summary extracted from

  • Vaquero, A.; Scher, M.B.; Lee, D.H.; Sutton, A.; Cheng, H.L.; Alt, F.W.; Serrano, L.; Sternglanz, R.; Reinberg, D.
    SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis (2006), Genes Dev., 20, 1256-1261.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.286 cytoplasm the enzyme is cytoplasmic during most of the cell cycle except in the G2/M transition and in mitosis Homo sapiens 5737
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2.3.1.286 nucleus in the G2/M transition and in mitosis the enzyme is localized in association with chromatin Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.286 NAD+ + [histone H4]-N6-acetyl-L-lysine16 Homo sapiens the deacetylation of [histone H4]-N6-acetyl-L-lysine16 may be pivotal to the formation of condensed chromatin nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.286 Homo sapiens Q8IXJ6
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.286
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.286 NAD+ + [histone H3]-N6-acetyl-L-lysine9 deacetylated at high concentrations of enzyme Homo sapiens nicotinamide + [histone H3]-L-lysine9 + 2'-O-acetyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + [histone H4]-N6-acetyl-L-lysine16 the deacetylation of [histone H4]-N6-acetyl-L-lysine16 may be pivotal to the formation of condensed chromatin Homo sapiens nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + [histone H4]-N6-acetyl-L-lysine16 strong preference for histone H4K16Ac in their deacetylation activity in vitro and in vivo Homo sapiens nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + [histone H4]-N6-acetyl-L-lysine8 deacetylated at high concentrations of enzyme Homo sapiens nicotinamide + [histone H4]-L-lysine8 + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.286 SIRT2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.286 metabolism the deacetylation of [histone H4]-N6-acetyl-L-lysine16 by Sirt2 may be pivotal to the formation of condensed chromatin Homo sapiens