Literature summary extracted from

Kasai, D.; Kamimura, N.; Tani, K.; Umeda, S.; Abe, T.; Fukuda, M.; Masai, E.
Characterization of FerC, a MarR-type transcriptional regulator, involved in transcriptional regulation of the ferulate catabolic operon in Sphingobium sp. strain SYK-6 (2012), FEMS Microbiol. Lett., 332, 68-75.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
4.1.2.61	gene ferB, the ferBA genes form an operon, genetic organization of the fer gene cluster, overview. Transcriptional regulation of ferBA controlled by a MarR-type transcriptional regulator, FerC. The ferC gene is located upstream of ferB. The transcription start site of ferB is mapped at 30 nucleotides upstream from the ferB initiation codon. Constitutive expression of the ferC-ferB intergenic region in SME043 cells, FerC regulates the ferBA transcription through the binding to the ferCferB intergenic region	Sphingobium sp.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4.1.2.61	feruloyl-CoA + H2O	Sphingobium sp.	-	4-hydroxy-3-methoxybenzaldehyde + acetyl-CoA	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.1.2.61	Sphingobium sp.	G2IJ08	gene ferB	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.1.2.61	culture condition:ferulate-grown cell	-	Sphingobium sp.	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.1.2.61	feruloyl-CoA + H2O	-	Sphingobium sp.	4-hydroxy-3-methoxybenzaldehyde + acetyl-CoA	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
4.1.2.61	feruloyl-CoA hydratase/lyase	-	Sphingobium sp.

Expression

EC Number	Organism	Comment	Expression
4.1.2.61	Sphingobium sp.	transcription of ferB is induced 6.5fold in the SYK-6 cells grown on ferulate	up

General Information

EC Number	General Information	Comment	Organism
4.1.2.61	malfunction	the ferB mutant FBK is scarcely able to transform feruloyl-CoA	Sphingobium sp.
4.1.2.61	metabolism	the enzyme catalyzes a step in the catabolic pathway of ferulate	Sphingobium sp.

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Release 2023.1 (January 2023)