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Literature summary extracted from

  • Mechaly, A.E.; Haouz, A.; Miras, I.; Barilone, N.; Weber, P.; Shepard, W.; Alzari, P.M.; Bellinzoni, M.
    Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis (2012), FEBS Lett., 586, 1606-1611.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.1.2 crystal structures of Mycobacterium tuberculosis Rv1098c in complex with L-malate, fumarate and the competitive inhibitor meso-tartrate is reported Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.2 S318A mutant shows no activity Mycobacterium tuberculosis
4.2.1.2 S318C mutant shows no activity Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.2 meso-tartrate
-
 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.2 Mycobacterium tuberculosis P9WN93
-
-
4.2.1.2 Mycobacterium tuberculosis ATCC 25618 P9WN93
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.2 fumarate + H2O
-
 Mycobacterium tuberculosis L-malate
-
 ?
4.2.1.2 fumarate + H2O
-
 Mycobacterium tuberculosis ATCC 25618 L-malate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.2 class II fumarase
-
 Mycobacterium tuberculosis
4.2.1.2 rv1098c
-
 Mycobacterium tuberculosis