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Literature summary extracted from

  • Lehneck, R.; Neumann, P.; Vullo, D.; Elleuche, S.; Supuran, C.T.; Ficner, R.; Poeggeler, S.
    Crystal structures of two tetrameric beta-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora (2014), FEBS J., 281, 1759-1772.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.1 expressed as a His-tagged fusion protein in Escherichia coli Sordaria macrospora

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.1.1 determined to a resolution of 2.7A Sordaria macrospora

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 acetazolamide
-
Sordaria macrospora
4.2.1.1 bromide
-
Sordaria macrospora
4.2.1.1 chloride
-
Sordaria macrospora
4.2.1.1 perchlorate
-
Sordaria macrospora
4.2.1.1 phenylarsonic acid
-
Sordaria macrospora
4.2.1.1 phenylboronic acid
-
Sordaria macrospora
4.2.1.1 sulfamate
-
Sordaria macrospora
4.2.1.1 sulfamide
-
Sordaria macrospora
4.2.1.1 sulfate
-
Sordaria macrospora
4.2.1.1 tetrafluoroborate
-
Sordaria macrospora

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.1 cytosol
-
Sordaria macrospora 5829
-
4.2.1.1 mitochondrion contain N-terminal signal peptide for translocation into mitochondria Sordaria macrospora 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.1 25100
-
calculated from cDNA Sordaria macrospora
4.2.1.1 25900
-
calculated from cDNA Sordaria macrospora

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Sordaria macrospora C1L335
-
-
4.2.1.1 Sordaria macrospora C1L336
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
Sordaria macrospora H2CO3
-
?

Subunits

EC Number Subunits Comment Organism
4.2.1.1 tetramer crystal structure Sordaria macrospora

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 beta-carbonic anhydrase
-
Sordaria macrospora
4.2.1.1 CAS1
-
Sordaria macrospora
4.2.1.1 CAS2
-
Sordaria macrospora

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.1.1 20
-
assay at Sordaria macrospora

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.1 12000
-
CO2 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 13000
-
CO2 20°C, pH 8.3 Sordaria macrospora

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.2.1.1 8.3
-
assay at Sordaria macrospora

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.000445
-
acetazolamide 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 0.000816
-
acetazolamide 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 0.009
-
phenylboronic acid 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 0.035
-
phenylarsonic acid 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 0.048
-
sulfamide 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 0.054
-
phenylarsonic acid 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 0.056
-
phenylboronic acid 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 0.069
-
sulfamate 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 0.072
-
sulfamate 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 0.084
-
sulfamide 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 4.8
-
sulfamide 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 9.2
-
chloride 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 9.3
-
bromide 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 100
-
chloride value above, 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 100
-
bromide value above, 20°C, pH 8.3 Sordaria macrospora

General Information

EC Number General Information Comment Organism
4.2.1.1 malfunction enzyme complements Saccharomyces cerevisiae deletion mutant Nce103 Sordaria macrospora

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.2.1.1 1210
-
CO2 20°C, pH 8.3 Sordaria macrospora
4.2.1.1 1300
-
CO2 20°C, pH 8.3 Sordaria macrospora