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Literature summary extracted from

  • Merrick, C.J.; Duraisingh, M.T.
    Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity (2007), Eukaryot. Cell, 6, 2081-291.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.B41 additional information the enzyme is unaffected by the activators isonicotinamide and resveratrol Plasmodium falciparum

Application

EC Number Application Comment Organism
2.3.1.B41 medicine PfSir2A inhibitors may have therapeutic value in malaria treatment Plasmodium falciparum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.B41 expressed in Escherichia coli with a C-terminal His6 tag and an N-terminal T7 tag Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.B41 additional information splitomicin and sirtinol fail to inhibit PfSir2 Plasmodium falciparum
2.3.1.B41 nicotinamide inhibits the deacetylation of native histones much more effectively than deacetylation of a synthetic substrate Plasmodium falciparum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.B41 30000
-
 x * 30000, SDS-PAGE Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B41 Plasmodium falciparum Q8IE47
-
-
2.3.1.B41 Plasmodium falciparum isolate 3D7 Q8IE47
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.B41
-
 Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B41 NAD+ + [histone H3]-N6-acetyl-L-lysine
-
 Plasmodium falciparum nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
2.3.1.B41 NAD+ + [histone H3]-N6-acetyl-L-lysine
-
 Plasmodium falciparum isolate 3D7 nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
2.3.1.B41 NAD+ + [histone H4]-N6-acetyl-L-lysine
-
 Plasmodium falciparum nicotinamide + [histone H4]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
2.3.1.B41 NAD+ + [histone H4]-N6-acetyl-L-lysine
-
 Plasmodium falciparum isolate 3D7 nicotinamide + [histone H4]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.B41 ? x * 30000, SDS-PAGE Plasmodium falciparum

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B41 Sir2A
-
 Plasmodium falciparum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.B41 37
-
 assay at Plasmodium falciparum