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Literature summary extracted from

  • Schmid, G.; Rene, S.B.; Boll, M.
    Enzymes of the benzoyl-coenzyme A degradation pathway in the hyperthermophilic archaeon Ferroglobus placidus (2015), Environ. Microbiol., 17, 3289-3300.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.35 expression in Escherichia coli Ferroglobus placidus
4.2.1.55 expression in Escherichia coli Ferroglobus placidus
4.2.1.100 expression in Escherichia coli Ferroglobus placidus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.35 3-hydroxybutyryl-CoA + NAD+ Ferroglobus placidus the enzyme is involved in benzoyl-coenzyme A degradation acetoacetyl-CoA + NADH
-
 ?
1.1.1.35 3-hydroxybutyryl-CoA + NAD+ Ferroglobus placidus DSM 10642 the enzyme is involved in benzoyl-coenzyme A degradation acetoacetyl-CoA + NADH
-
 ?
4.2.1.55 crotonoyl-CoA + H2O Ferroglobus placidus the enzyme is involved in benzoyl-coenzyme A degradation (3R)-3-hydroxybutanoyl-CoA
-
 ?
4.2.1.55 crotonoyl-CoA + H2O Ferroglobus placidus DSM 10642 the enzyme is involved in benzoyl-coenzyme A degradation (3R)-3-hydroxybutanoyl-CoA
-
 ?
4.2.1.100 cyclohexa-1,5-diene-1-carbonyl-CoA + H2O Ferroglobus placidus the enzyme is involved in benzoyl-coenzyme A degradation 6-hydroxycyclohex-1-ene-1-carbonyl-CoA
-
 ?
4.2.1.100 cyclohexa-1,5-diene-1-carbonyl-CoA + H2O Ferroglobus placidus DSM 10642 the enzyme is involved in benzoyl-coenzyme A degradation 6-hydroxycyclohex-1-ene-1-carbonyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.35 Ferroglobus placidus D3RXI4
-
-
1.1.1.35 Ferroglobus placidus DSM 10642 D3RXI4
-
-
1.3.7.8 Ferroglobus placidus
-
-
-
4.2.1.55 Ferroglobus placidus D3RXI4
-
-
4.2.1.55 Ferroglobus placidus DSM 10642 D3RXI4
-
-
4.2.1.100 Ferroglobus placidus D3RXI0
-
-
4.2.1.100 Ferroglobus placidus DSM 10642 D3RXI0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.35 culture condition:benzoate-grown cell
-
 Ferroglobus placidus
-
1.3.7.8 culture condition:benzoate-grown cell
-
 Ferroglobus placidus
-
4.2.1.55 culture condition:benzoate-grown cell
-
 Ferroglobus placidus
-
4.2.1.100 culture condition:benzoate-grown cell
-
 Ferroglobus placidus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.35 0.5
-
 85°C, pH 7.0, highly enriched enzyme Ferroglobus placidus
4.2.1.55 5.7
-
 85°C, pH 7.0, highly enriched enzyme Ferroglobus placidus
4.2.1.100 31.7
-
 85°C, pH 7.0, highly enriched enzyme Ferroglobus placidus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.35 3-hydroxybutyryl-CoA + NAD+
-
 Ferroglobus placidus acetoacetyl-CoA + NADH
-
 ?
1.1.1.35 3-hydroxybutyryl-CoA + NAD+ the enzyme is involved in benzoyl-coenzyme A degradation Ferroglobus placidus acetoacetyl-CoA + NADH
-
 ?
1.1.1.35 3-hydroxybutyryl-CoA + NAD+
-
 Ferroglobus placidus DSM 10642 acetoacetyl-CoA + NADH
-
 ?
1.1.1.35 3-hydroxybutyryl-CoA + NAD+ the enzyme is involved in benzoyl-coenzyme A degradation Ferroglobus placidus DSM 10642 acetoacetyl-CoA + NADH
-
 ?
4.2.1.55 crotonoyl-CoA + H2O
-
 Ferroglobus placidus (3R)-3-hydroxybutanoyl-CoA
-
 ?
4.2.1.55 crotonoyl-CoA + H2O the enzyme is involved in benzoyl-coenzyme A degradation Ferroglobus placidus (3R)-3-hydroxybutanoyl-CoA
-
 ?
4.2.1.55 crotonoyl-CoA + H2O
-
 Ferroglobus placidus DSM 10642 (3R)-3-hydroxybutanoyl-CoA
-
 ?
4.2.1.55 crotonoyl-CoA + H2O the enzyme is involved in benzoyl-coenzyme A degradation Ferroglobus placidus DSM 10642 (3R)-3-hydroxybutanoyl-CoA
-
 ?
4.2.1.100 cyclohexa-1,5-diene-1-carbonyl-CoA + H2O
-
 Ferroglobus placidus 6-hydroxycyclohex-1-ene-1-carbonyl-CoA
-
 ?
4.2.1.100 cyclohexa-1,5-diene-1-carbonyl-CoA + H2O the enzyme is involved in benzoyl-coenzyme A degradation Ferroglobus placidus 6-hydroxycyclohex-1-ene-1-carbonyl-CoA
-
 ?
4.2.1.100 cyclohexa-1,5-diene-1-carbonyl-CoA + H2O
-
 Ferroglobus placidus DSM 10642 6-hydroxycyclohex-1-ene-1-carbonyl-CoA
-
 ?
4.2.1.100 cyclohexa-1,5-diene-1-carbonyl-CoA + H2O the enzyme is involved in benzoyl-coenzyme A degradation Ferroglobus placidus DSM 10642 6-hydroxycyclohex-1-ene-1-carbonyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.35 Ferp_1035 gene name. Bifunctional crotonase/3-OH-butyryl-CoA dehydrogenase Ferroglobus placidus
4.2.1.55 Ferp_1035 gene name. Bifunctional crotonase/3-OH-butyryl-CoA dehydrogenase Ferroglobus placidus
4.2.1.100 Ferp_1031
-
 Ferroglobus placidus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.35 85
-
 assay at Ferroglobus placidus
4.2.1.55 85
-
 assay at Ferroglobus placidus
4.2.1.100 85
-
 assay at Ferroglobus placidus

General Information

EC Number General Information Comment Organism
1.1.1.35 metabolism the enzyme is involved in benzoyl-coenzyme A degradation Ferroglobus placidus
4.2.1.55 metabolism the enzyme is involved in benzoyl-coenzyme A degradation Ferroglobus placidus
4.2.1.100 metabolism the enzyme is involved in benzoyl-coenzyme A degradation Ferroglobus placidus