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Literature summary extracted from

  • Percudani, R.; Carnevali, D.; Puggioni, V.
    Ureidoglycolate hydrolase, amidohydrolase, lyase: how errors in biological databases are incorporated in scientific papers and vice versa (2013), Database (Oxford), 2013, bat071.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.2.3 gene allA, encoded in the ALL locus Escherichia coli
4.3.2.3 gene DAL3, the DAL metabolic gene cluster, the so called degradation of allantoin locus, is located on chromosome IX Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.2.3 EDTA complete inhibition, the activity can only be rescued by an excess of Ni2+ ions, not by other metal ions, i.e. Ca2+, Co2+, Cu2+, Mg2+, Mn2+, Zn2+, and Fe2+ Escherichia coli
4.3.2.3 EDTA complete inhibition Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.3.2.3 Ni2+ nickel-dependent urea-release activity Escherichia coli
4.3.2.3 Ni2+ nickel-dependent urea-release activity Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.116 (S)-ureidoglycolate + H2O Glycine max
-
 2 NH3 + CO2 + glyoxylate
-
 ?
3.5.1.116 (S)-ureidoglycolate + H2O Arabidopsis thaliana
-
 2 NH3 + CO2 + glyoxylate
-
 ?
4.3.2.3 (S)-ureidoglycolate Escherichia coli nickel-dependent urea-release activity glyoxylate + urea
-
 ?
4.3.2.3 (S)-ureidoglycolate Saccharomyces cerevisiae nickel-dependent urea-release activity glyoxylate + urea
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.116 Arabidopsis thaliana Q8VXY9
-
-
3.5.1.116 Glycine max
-
-
-
4.3.2.3 Escherichia coli P63486 gene allA
-
4.3.2.3 Saccharomyces cerevisiae P32459 gene dal3
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.116 (S)-ureidoglycolate + H2O
-
 Glycine max 2 NH3 + CO2 + glyoxylate
-
 ?
3.5.1.116 (S)-ureidoglycolate + H2O
-
 Arabidopsis thaliana 2 NH3 + CO2 + glyoxylate
-
 ?
3.5.1.116 (S)-ureidoglycolate + H2O a hydrolytic reaction caused by the attack of water to the amidic bond of ureidoglycolate, with formation of carbamate and hydroxyglycine as primary products Glycine max 2 NH3 + CO2 + glyoxylate
-
 ?
3.5.1.116 (S)-ureidoglycolate + H2O a hydrolytic reaction caused by the attack of water to the amidic bond of ureidoglycolate, with formation of carbamate and hydroxyglycine as primary products Arabidopsis thaliana 2 NH3 + CO2 + glyoxylate
-
 ?
4.3.2.3 (S)-ureidoglycolate nickel-dependent urea-release activity Escherichia coli glyoxylate + urea
-
 ?
4.3.2.3 (S)-ureidoglycolate nickel-dependent urea-release activity Saccharomyces cerevisiae glyoxylate + urea
-
 ?
4.3.2.3 additional information recombinant enzyme from Escherichia coli is unable to release ammonia directly from ureidoglycolate Escherichia coli ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.116 UAH
-
 Arabidopsis thaliana
3.5.1.116 ureidoglycolate hydrolase
-
 Glycine max
3.5.1.116 ureidoglycolate hydrolase
-
 Arabidopsis thaliana
4.3.2.3 allA
-
 Escherichia coli
4.3.2.3 DAL3
-
 Saccharomyces cerevisiae
4.3.2.3 ureidoglycolate lyase, releasing urea
-
 Escherichia coli
4.3.2.3 ureidoglycolate lyase, releasing urea
-
 Saccharomyces cerevisiae
4.3.2.3 YIR032C UniProt Saccharomyces cerevisiae

Expression

EC Number Organism Comment Expression
4.3.2.3 Escherichia coli the locus encoding the enzyme is expressed under anaerobiosis and nitrogen starvation up

General Information

EC Number General Information Comment Organism
4.3.2.3 malfunction DAL3 deletion abolishes the activity on ureidoglycolate Saccharomyces cerevisiae
4.3.2.3 additional information the AllA structure reveals two gracious small barrel (cupin) folds Escherichia coli