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Literature summary extracted from

  • Yang, W.; Schmid, E.; Nurbaeva, M.K.; Szteyn, K.; Leibrock, C.; Yan, J.; Schaller, M.; Gulbins, E.; Shumilina, E.; Lang, F.
    Role of acid sphingomyelinase in the regulation of mast cell function (2014), Clin. Exp. Allergy, 44, 79-90.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.4.12 pharmacology the enzyme is a potential target in the treatment of allergic reactions Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 amitriptyline
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 a sphingomyelin + H2O Mus musculus
-
 a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 mast cell isolated from bone marrow or peritoneal lavage of gene-targeted mice lacking Asm and their wild-type littermates Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 a sphingomyelin + H2O
-
 Mus musculus a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
 Mus musculus
3.1.4.12 ASM
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 5
-
 assay at Mus musculus

Expression

EC Number Organism Comment Expression
3.1.4.12 Mus musculus stimulation of bone marrow-derived mast cells with antigen results in about 2.5fold induction of enzyme activity up

General Information

EC Number General Information Comment Organism
3.1.4.12 physiological function the enzyme is a regulator of mast cell function, detailed overview. Degranulation of mast cells is stimulated by store-operated Ca2+-entry, while in other cell types, Ca2+-entry is modified by ceramide. Exogenously added ceramide has been shown to trigger mast cell apoptosis. Ceramide is produced from sphingomyelin by acid sphingomyelinase. Decrease in body temperature upon the induction of systemic anaphylaxis is significantly less pronounced in asm-/- mice than in asm+/+ mice Mus musculus