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Literature summary extracted from

  • PuthanVeetil, V.; Raj, H.; DeVilliers, M.; Tepper, P.; Dekker, F.; Quax, W.; Poelarends, G.
    Enantioselective Synthesis of N-Substituted Aspartic Acids Using an Engineered Variant of Methylaspartate Ammonia Lyase (2013), ChemCatChem, 5, 1325-1327.
No PubMed abstract available

Protein Variants

EC Number Protein Variants Comment Organism
4.3.1.2 Q73A analysis carried out with mutant Q73A. The potential of the mutant Q73A enzyme is shown for application in the asymmetric synthesis of a large variety of valuable N-substituted l-aspartic acids Clostridium tetanomorphum

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.2 Clostridium tetanomorphum Q05514
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.2 mesaconate + (aminooxy)ethane mutant Q73A, conversion: 100%, yield: 61% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + 1-cyclopropylmethanamine mutant Q73A, conversion: 96%, yield: 28%, enantiomeric excess: more than 99% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + 2-methoxyethanamine mutant Q73A, conversion: 100%, yield: 53% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + 3-aminopropan-1-ol mutant Q73A, conversion: 99%, yield: 57% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + aminobutane mutant Q73A, conversion: 97%, yield: 33%, enantiomeric excess: more than 99% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + cyclobutanamine mutant Q73A, conversion: 99%, yield: 74%, enantiomeric excess: more than 99% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + cyclopropanamine mutant Q73A, conversion: 100%, yield: 48% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + ethanamine mutant Q73A, conversion: 100%, yield: 75%, enantiomeric excess: more than 99% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + ethane-1,2-diamine mutant Q73A, conversion: 99%, yield: 67% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + methanamine mutant Q73A, conversion: 100%, yield: 96%, enantiomeric excess: more than 99% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + NH3 mutant Q73A, conversion: 100%, yield: 79%, enantiomeric excess: more than 99% Clostridium tetanomorphum L-threo-3-methylaspartate
-
 r
4.3.1.2 mesaconate + pentanamine mutant Q73A, conversion: 91%, yield: 14%, enantiomeric excess: more than 99% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + propanamine mutant Q73A, conversion: 99%, yield: 53%, enantiomeric excess: more than 99% Clostridium tetanomorphum ?
-
 r
4.3.1.2 mesaconate + propane-1,3-diamine mutant Q73A, conversion: 100%, yield: 61% Clostridium tetanomorphum ?
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.3.1.2 MAL
-
 Clostridium tetanomorphum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.3.1.2 22
-
 assay at Clostridium tetanomorphum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.3.1.2 9
-
 assay at Clostridium tetanomorphum