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Literature summary extracted from

  • Perez, M.; Lombo, F.; Zhu, L.; Gibson, M.; Brana, A.F.; Rohr, J.; Salas, J.A.; Mendez, C.
    Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins (2005), Chem. Commun. (Camb. ), 2005, 1604-1606.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.331 medicine generation of L- and D-stereoisomers of amicetose by combining sugar biosynthesis genes from four different antibiotic gene clusters and transfer of both sugars to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase to yield antitumor tetracenomycins Streptomyces olivaceus
2.4.1.331 synthesis generation of L- and D-stereoisomers of amicetose by combining sugar biosynthesis genes from four different antibiotic gene clusters and transfer of both sugars to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase to yield antitumor tetracenomycins Streptomyces olivaceus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.331 Streptomyces olivaceus Q9F2F9
-
-
2.4.1.331 Streptomyces olivaceus Tü2353 Q9F2F9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.331 NDP-D-amicetose + 8-demethyltetracenomycin C
-
 Streptomyces olivaceus NDP + 8-demethyl-8-alpha-D-amicetyltetracenomycin C
-
 ?
2.4.1.331 NDP-D-amicetose + 8-demethyltetracenomycin C
-
 Streptomyces olivaceus Tü2353 NDP + 8-demethyl-8-alpha-D-amicetyltetracenomycin C
-
 ?
2.4.1.331 NDP-L-amicetose + 8-demethyltetracenomycin C
-
 Streptomyces olivaceus NDP + 8-demethyl-8-alpha-L-amicetyltetracenomycin C
-
 ?
2.4.1.331 NDP-L-amicetose + 8-demethyltetracenomycin C
-
 Streptomyces olivaceus Tü2353 NDP + 8-demethyl-8-alpha-L-amicetyltetracenomycin C
-
 ?