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Literature summary extracted from

  • Motohashi, S.; Koizumi, K.; Honda, R.; Maruyama, A.; Palmer, H.E.; Mashima, K.
    Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners (2014), Cell. Immunol., 289, 128-134.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.48 [a protein]-tyrosine phosphate + H2O Rattus norvegicus
-
 [a protein]-tyrosine + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.48 phosphoprotein aggregation of the high-affinity IgE receptor FceRI induces the phosphorylation of PTP-PEST at Ser39, thus resulting in the suppression of enzyme activity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 basophilic leukemia cell
-
 Rattus norvegicus
-
3.1.3.48 RBL-2H3 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 [a protein]-tyrosine phosphate + H2O
-
 Rattus norvegicus [a protein]-tyrosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 protein tyrosine phosphatase-PEST
-
 Rattus norvegicus
3.1.3.48 PTP-PEST
-
 Rattus norvegicus
3.1.3.48 PTPN12
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.1.3.48 Rattus norvegicus PTP-PEST mRNA expression is significantly induced upon the high-affinity IgE receptor FceRI-crosslinking up

General Information

EC Number General Information Comment Organism
3.1.3.48 physiological function protein tyrosine phosphatase-PEST regulates mast cell-activating signals in protein tyrosine phosphatase activity-dependent and -independent manners Rattus norvegicus