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Literature summary extracted from

  • Cipolla, L.; Sgambato, A.; Forcella, M.; Fusi, P.; Parenti, P.; Cardona, F.; Bini, D.
    N-Bridged 1-deoxynojirimycin dimers as selective insect trehalase inhibitors (2014), Carbohydr. Res., 389, 46-49.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.28 1,2-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)ethane-1,2-dione micromolar inhibitor Chironomus riparius
3.2.1.28 1,2-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)ethane-1,2-dione micromolar inhibitor Sus scrofa
3.2.1.28 1,3-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)propane-1,3-dione micromolar inhibitor Chironomus riparius
3.2.1.28 1,4-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)butane-1,4-dione micromolar inhibitor Chironomus riparius
3.2.1.28 1,4-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)butane-1,4-dione micromolar inhibitor Sus scrofa
3.2.1.28 1-deoxynojirimycin
-
 Chironomus riparius
3.2.1.28 1-deoxynojirimycin
-
 Sus scrofa
3.2.1.28 casuarine-6-O-alpha-D-glucoside
-
 Chironomus riparius
3.2.1.28 casuarine-6-O-alpha-D-glucoside
-
 Sus scrofa
3.2.1.28 additional information not inhibited by 1,3-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)propane-1,3-dione Sus scrofa
3.2.1.28 trehazolin
-
 Chironomus riparius
3.2.1.28 trehazolin
-
 Sus scrofa
3.2.1.28 validoxylamine A
-
 Chironomus riparius
3.2.1.28 validoxylamine A
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.28 alpha,alpha-trehalose + H2O Sus scrofa
-
 beta-D-glucose + alpha-D-glucose
-
 ?
3.2.1.28 alpha,alpha-trehalose + H2O Chironomus riparius
-
 beta-D-glucose + alpha-D-glucose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.28 Chironomus riparius J7EJ73
-
-
3.2.1.28 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.28 larva
-
 Chironomus riparius
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.28 alpha,alpha-trehalose + H2O
-
 Sus scrofa beta-D-glucose + alpha-D-glucose
-
 ?
3.2.1.28 alpha,alpha-trehalose + H2O
-
 Chironomus riparius beta-D-glucose + alpha-D-glucose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.28 alpha-glucoside-1-glucohydrolase
-
 Sus scrofa
3.2.1.28 alpha-glucoside-1-glucohydrolase
-
 Chironomus riparius
3.2.1.28 trehalase
-
 Sus scrofa
3.2.1.28 trehalase
-
 Chironomus riparius

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.28 0.00283
-
 at pH 6.9 and 30°C Chironomus riparius 1-deoxynojirimycin
3.2.1.28 0.00596
-
 at pH 6.9 and 30°C Sus scrofa 1-deoxynojirimycin
3.2.1.28 0.0061
-
 at pH 6.9 and 30°C Chironomus riparius 1,2-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)ethane-1,2-dione
3.2.1.28 0.011
-
 at pH 6.9 and 30°C Chironomus riparius 1,4-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)butane-1,4-dione
3.2.1.28 0.024
-
 at pH 6.9 and 30°C Sus scrofa 1,2-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)ethane-1,2-dione
3.2.1.28 0.076
-
 at pH 6.9 and 30°C Sus scrofa 1,4-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)butane-1,4-dione
3.2.1.28 0.223
-
 at pH 6.9 and 30°C Chironomus riparius 1,3-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)propane-1,3-dione