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Literature summary extracted from

  • Ming, M.; Han, W.; Zhao, B.; Sundaresan, N.R.; Deng, C.X.; Gupta, M.P.; He, Y.Y.
    SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer (2014), Cancer Res., 74, 5925-5933.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.B41 medicine the oncogenic role of SIRT6 in skin cancer suggest SIRT6 as a potential target for developing chemopreventive strategies to reduce the skin cancer Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B41 Homo sapiens Q8N6T7
-
-
2.3.1.B41 Mus musculus P59941
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.B41 keratinocyte epidermal Homo sapiens
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2.3.1.B41 skin
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 Mus musculus
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2.3.1.B41 skin sun-protected normal skin Homo sapiens
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2.3.1.B41 squamous cell carcinoma cell
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 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B41 SIRT6
-
 Homo sapiens
2.3.1.B41 SIRT6
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.3.1.B41 Homo sapiens SIRT6 is upregulated in squamous cell carcinoma up

General Information

EC Number General Information Comment Organism
2.3.1.B41 malfunction SIRT6 loss suppresses proliferation and epidermal hyperplasia in mouse skin. Skin-specific deletion of SIRT6 in the mouse inhibits skin tumorigenesis Mus musculus
2.3.1.B41 metabolism SIRT6 upregulates COX-2 levels and acts as an oncogene in skin carcinogenesis Homo sapiens
2.3.1.B41 metabolism SIRT6 upregulates COX-2 levels and acts as an oncogene in skin carcinogenesis Mus musculus