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Literature summary extracted from

  • Reveal, B.S.; Paietta, J.V.
    Analysis of the sulfur-regulated control of the cystathionine gamma-lyase gene of Neurospora crassa (2012), BMC Res. Notes, 5, 339.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.4.1.1 CYS3 a bZIP transcriptional activator, is the key regulator and necessary for regulation expression of the sulfur-related genes, binds on a consensus sequence for CYS3 binding Neurospora crassa

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.1 gene cys-16+, DNA and amino acid sequence determination and analysis, gene cys-16+ gene encodes a polypeptide of 417 amino acids with a highly conserved pyridoxal 5'-phosphate binding site and substrate-cofactor binding pocket Neurospora crassa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.1 L-cystathionine + H2O Neurospora crassa
-
 L-cysteine + 2-oxobutanoate + NH3
-
 ?
4.4.1.1 L-cystathionine + H2O Neurospora crassa 74OR23-1a
-
 L-cysteine + 2-oxobutanoate + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.1 Neurospora crassa Q96VU7 gene cys-16+
-
4.4.1.1 Neurospora crassa 74OR23-1a Q96VU7 gene cys-16+
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.1 L-cystathionine + H2O
-
 Neurospora crassa L-cysteine + 2-oxobutanoate + NH3
-
 ?
4.4.1.1 L-cystathionine + H2O
-
 Neurospora crassa 74OR23-1a L-cysteine + 2-oxobutanoate + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.1 gamma-cystathionase
-
 Neurospora crassa

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.1 pyridoxal 5'-phosphate
-
 Neurospora crassa

Expression

EC Number Organism Comment Expression
4.4.1.1 Neurospora crassa enzyme expression levels are present only at a low level under sulfur sufficient (repressing) conditions down
4.4.1.1 Neurospora crassa cys-16+ transcript levels in a activator/regulator CYS3-defective DELTAcys-3 regulatory mutant are present at a low level under either derepressing or repressing conditions additional information
4.4.1.1 Neurospora crassa enzyme expression levels increase under sulfur limiting (derepressing) conditions up