BRENDA - Enzyme Database

Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome

Kim, J.H.; Ryu, Y.B.; Lee, W.S.; Kim, Y.H.; Bioorg. Med. Chem. 22, 6047-6052 (2014)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.2.1.18
Berberine
reversible non-competitive inhibition
Clostridium perfringens
3.2.1.18
coptisine
-
Clostridium perfringens
3.2.1.18
curcumin
-
Clostridium perfringens
3.2.1.18
dehydrocorybulbine
-
Clostridium perfringens
3.2.1.18
glaucine
-
Clostridium perfringens
3.2.1.18
Jatrorrhizine
-
Clostridium perfringens
3.2.1.18
additional information
a 95% (v/v) ethanol extract of Corydalis turtschaninovii rhizome shows neuraminidase inhibitory activity (68% at 0.03 mg/ml); not inhibited by corydaline and tetrahydrocoptisine
Clostridium perfringens
3.2.1.18
palmatine
reversible non-competitive inhibition
Clostridium perfringens
3.2.1.18
pseudocoptisine
-
Clostridium perfringens
3.2.1.18
pseudodehydrocorydaline
-
Clostridium perfringens
3.2.1.18
tetrahydrocoptisine
-
Clostridium perfringens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.2.1.18
Clostridium perfringens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.2.1.18
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
-
729397
Clostridium perfringens
4-methylumbelliferone + N-acetylneuraminic acid
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.2.1.18
0.006
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
curcumin
3.2.1.18
0.0128
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
palmatine
3.2.1.18
0.0135
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
Berberine
3.2.1.18
0.0251
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
coptisine
3.2.1.18
0.0326
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
pseudodehydrocorydaline
3.2.1.18
0.037
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
Jatrorrhizine
3.2.1.18
0.0413
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
dehydrocorybulbine
3.2.1.18
0.0652
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
pseudocoptisine
3.2.1.18
0.0969
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
glaucine
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.2.1.18
0.006
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
curcumin
3.2.1.18
0.0128
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
palmatine
3.2.1.18
0.0135
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
Berberine
3.2.1.18
0.0251
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
coptisine
3.2.1.18
0.0326
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
pseudodehydrocorydaline
3.2.1.18
0.037
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
Jatrorrhizine
3.2.1.18
0.0413
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
dehydrocorybulbine
3.2.1.18
0.0652
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
pseudocoptisine
3.2.1.18
0.0969
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
Clostridium perfringens
glaucine
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.2.1.18
Berberine
reversible non-competitive inhibition
Clostridium perfringens
3.2.1.18
coptisine
-
Clostridium perfringens
3.2.1.18
curcumin
-
Clostridium perfringens
3.2.1.18
dehydrocorybulbine
-
Clostridium perfringens
3.2.1.18
glaucine
-
Clostridium perfringens
3.2.1.18
Jatrorrhizine
-
Clostridium perfringens
3.2.1.18
additional information
a 95% (v/v) ethanol extract of Corydalis turtschaninovii rhizome shows neuraminidase inhibitory activity (68% at 0.03 mg/ml); not inhibited by corydaline and tetrahydrocoptisine
Clostridium perfringens
3.2.1.18
palmatine
reversible non-competitive inhibition
Clostridium perfringens
3.2.1.18
pseudocoptisine
-
Clostridium perfringens
3.2.1.18
pseudodehydrocorydaline
-
Clostridium perfringens
3.2.1.18
tetrahydrocoptisine
-
Clostridium perfringens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.2.1.18
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
-
729397
Clostridium perfringens
4-methylumbelliferone + N-acetylneuraminic acid
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
3.2.1.18
physiological function
the enzyme plays a pivotal role in bacterial proliferation
Clostridium perfringens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.2.1.18
physiological function
the enzyme plays a pivotal role in bacterial proliferation
Clostridium perfringens