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Literature summary extracted from

  • Kim, J.H.; Ryu, Y.B.; Lee, W.S.; Kim, Y.H.
    Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome (2014), Bioorg. Med. Chem., 22, 6047-6052.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.18 Berberine reversible non-competitive inhibition Clostridium perfringens
3.2.1.18 coptisine
-
 Clostridium perfringens
3.2.1.18 curcumin
-
 Clostridium perfringens
3.2.1.18 dehydrocorybulbine
-
 Clostridium perfringens
3.2.1.18 glaucine
-
 Clostridium perfringens
3.2.1.18 Jatrorrhizine
-
 Clostridium perfringens
3.2.1.18 additional information a 95% (v/v) ethanol extract of Corydalis turtschaninovii rhizome shows neuraminidase inhibitory activity (68% at 0.03 mg/ml); not inhibited by corydaline and tetrahydrocoptisine Clostridium perfringens
3.2.1.18 palmatine reversible non-competitive inhibition Clostridium perfringens
3.2.1.18 pseudocoptisine
-
 Clostridium perfringens
3.2.1.18 pseudodehydrocorydaline
-
 Clostridium perfringens
3.2.1.18 tetrahydrocoptisine
-
 Clostridium perfringens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.18 Clostridium perfringens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.18 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
-
 Clostridium perfringens 4-methylumbelliferone + N-acetylneuraminic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.18 neuraminidase
-
 Clostridium perfringens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.18 0.006
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens curcumin
3.2.1.18 0.0128
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens palmatine
3.2.1.18 0.0135
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens Berberine
3.2.1.18 0.0251
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens coptisine
3.2.1.18 0.0326
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens pseudodehydrocorydaline
3.2.1.18 0.037
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens Jatrorrhizine
3.2.1.18 0.0413
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens dehydrocorybulbine
3.2.1.18 0.0652
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens pseudocoptisine
3.2.1.18 0.0969
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens glaucine

General Information

EC Number General Information Comment Organism
3.2.1.18 physiological function the enzyme plays a pivotal role in bacterial proliferation Clostridium perfringens